| Election Name: | 1922 United States Senate special election in Pennsylvania |
| Country: | Pennsylvania |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1920 United States Senate election in Pennsylvania |
| Previous Year: | 1920 |
| Next Election: | 1926 United States Senate election in Pennsylvania |
| Next Year: | 1926 |
| Election Date: | November 7, 1922 |
| Nominee1: | George Pepper |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 819,507 |
| Percentage1: | 57.60% |
| Nominee2: | Fred Kerr |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 468,330 |
| Percentage2: | 32.91% |
| Map Size: | 250px |
| U.S. Senator | |
| Before Election: | George Pepper |
| Before Party: | Republican Party (United States) |
| After Election: | George Pepper |
| After Party: | Republican Party (United States) |
The 1922 United States Senate special election in Pennsylvania was held on November 7, 1922. Incumbent Republican Senator George Pepper, who had been appointed to the seat by Governor William Sproul following the death of Boies Penrose, was elected to fill the remaining four years on the term to which Penrose had been elected in 1920. Pepper comfortably defeated five other candidates, including Democratic nominee Fred Kerr of Clearfield County.[1]
Incumbent Senator Boies Penrose, who had been elected in 1920 for a term expiring in 1927, died on December 31, 1921. Governor of Pennsylvania William Cameron Sproul appointed George W. Pepper to fill Penrose's seat until a successor could be duly elected. The special election for the remainder of Penrose's term was scheduled for November 7, simultaneous with the general election.
Primary elections were held on May 16.[2] Pepper was a candidate to complete the term.
After losing the Republican primary, Burke campaigned as the Progressive nominee in the regularly scheduled election for Pennsylvania's other U.S. Senate seat.