| Election Name: | 1952 United States Senate special election in Kentucky |
| Country: | Kentucky |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1948 United States Senate election in Kentucky |
| Previous Year: | 1948 |
| Next Election: | 1954 United States Senate election in Kentucky |
| Next Year: | 1954 |
| Election Date: | November 4, 1952 |
| Nominee1: | John Sherman Cooper |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 494,576 |
| Percentage1: | 51.51% |
| Nominee2: | Thomas R. Underwood |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 465,652 |
| Percentage2: | 48.49% |
| Map Size: | 300px |
| U.S. Senator | |
| Before Election: | Thomas R. Underwood |
| Before Party: | Democratic Party (United States) |
| After Election: | John Sherman Cooper |
| After Party: | Republican Party (United States) |
The 1952 United States Senate special election in Kentucky was held on November 4, 1952, to complete the unexpired term of the late Senator Virgil Chapman. Interim Senator Thomas R. Underwood ran to complete the term but was defeated by Republican former Senator John Sherman Cooper.
Incumbent Senator Virgil Chapman died on March 8, 1951. Governor Lawrence Wetherby appointed Thomas R. Underwood to fill the vacant seat until a successor could be duly elected. The special election was scheduled for November 4, 1952, concurrent with the general election for president and United States House of Representatives.