| Election Name: | 1996 United States Senate election in Wyoming |
| Country: | Wyoming |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1990 United States Senate election in Wyoming |
| Previous Year: | 1990 |
| Next Election: | 2002 United States Senate election in Wyoming |
| Next Year: | 2002 |
| Election Date: | November 5, 1996 |
| Image1: | File:Mike Enzi official portrait.jpg |
| Nominee1: | Mike Enzi |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 114,116 |
| Percentage1: | 54.06% |
| Nominee2: | Kathy Karpan |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 89,103 |
| Percentage2: | 42.21% |
| Map Size: | 255px |
| U.S. Senator | |
| Before Election: | Alan K. Simpson |
| Before Party: | Republican Party (United States) |
| After Election: | Mike Enzi |
| After Party: | Republican Party (United States) |
The 1996 United States Senate election in Wyoming was held November 5, 1996. Incumbent Republican U.S. Senator Alan K. Simpson decided to retire. Republican nominee Mike Enzi won the open seat.