| Election Name: | 1942 Democratic Senate primary in South Carolina |
| Country: | South Carolina |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1941 United States Senate special election in South Carolina |
| Previous Year: | 1941 (special) |
| Next Election: | 1948 United States Senate election in South Carolina |
| Next Year: | 1948 |
| Election Date: | August 25, 1942 |
| Image1: | Burnet R. Maybank.jpg |
| Nominee1: | Burnet R. Maybank |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 120,731 |
| Percentage1: | 51.38% |
| Nominee2: | Eugene Blease |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 114,241 |
| Percentage2: | 48.62% |
| Map Size: | 250px |
| U.S. Senator | |
| Before Election: | Burnet R. Maybank |
| Before Party: | Democratic Party (United States) |
| After Election: | Burnet R. Maybank |
| After Party: | Democratic Party (United States) |
The 1942 South Carolina United States Senate election was held on November 3, 1942 to select the U.S. Senator from the state of South Carolina. Incumbent Senator Burnet R. Maybank defeated Eugene S. Blease in the Democratic primary and was unopposed in the general election to win a six-year term.
See main article: 1941 United States Senate special election in South Carolina. In 1937, Senator James F. Byrnes began a six-year term ending in 1943, but President Franklin D. Roosevelt appointed him to the Supreme Court in 1940. To fill the vacancy until a successor could be duly elected, Governor of South Carolina Burnet R. Maybank appointed Judge Alva Lumpkin, but Lumpkin died on August 1, 1941. Maybank then appointed Roger C. Peace to succeed Lumpkin. Peace did not run in the special election to complete the term.
In the special election to complete Byrnes's unexpired term on November, Governor Maybank defeated former Governor Olin D. Johnston.
Maybank campaigned in support of the Roosevelt administration and defeated Blease in the primary election on August 25.
There was no opposition to the Democratic candidate in the general election so Maybank was elected to a six-year term in the Senate.
|-| | colspan=5 |Democratic hold|-