| Election Name: | 2000 United States Senate election in Ohio |
| Country: | Ohio |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1994 United States Senate election in Ohio |
| Previous Year: | 1994 |
| Next Election: | 2006 United States Senate election in Ohio |
| Next Year: | 2006 |
| Election Date: | November 7, 2000 |
| Turnout: | 63.6% (Registered Voters) |
| Image1: | File:Mike DeWine official photo.jpg |
| Nominee1: | Mike DeWine |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 2,665,512 |
| Percentage1: | 59.92% |
| Nominee2: | Ted Celeste |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 1,595,066 |
| Percentage2: | 35.85% |
| Map Size: | 210px |
| U.S. Senator | |
| Before Election: | Mike DeWine |
| Before Party: | Republican Party (United States) |
| After Election: | Mike DeWine |
| After Party: | Republican Party (United States) |
The 2000 United States Senate election in Ohio took place on November 7, 2000. Incumbent Senator Mike DeWine won re-election to a second term. His victory made him the first Republican re-elected to the Senate in Ohio since John W. Bricker in 1952. As of 2024, this is the last time that the Republicans won Ohio’s Class 1 Senate seat.