| Election Name: | 1978 United States Senate election in North Carolina |
| Country: | North Carolina |
| Flag Year: | 1885 |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1972 United States Senate election in North Carolina |
| Previous Year: | 1972 |
| Next Election: | 1984 United States Senate election in North Carolina |
| Next Year: | 1984 |
| Election Date: | November 7, 1978 |
| Image1: | Jesse Helms.jpg |
| Nominee1: | Jesse Helms |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 619,151 |
| Percentage1: | 54.51% |
| Nominee2: | John Ingram |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 516,663 |
| Percentage2: | 45.49% |
| Map Size: | 325px |
| U.S. Senator | |
| Before Election: | Jesse Helms |
| Before Party: | Republican Party (United States) |
| After Election: | Jesse Helms |
| After Party: | Republican Party (United States) |
The North Carolina United States Senate election of 1978 was held on November 7, 1978 as part of the nationwide elections to the Senate. The general election was between the Republican incumbent Jesse Helms and the Democratic nominee John Ingram. Helms won re-election, by a slightly wider margin than in 1972. This was the first Senate election where Republicans were re-elected.
Jesse Helms won the Republican Party's nomination unopposed.