| Election Name: | 1986 United States Senate election in Missouri |
| Country: | Missouri |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1980 United States Senate election in Missouri |
| Previous Year: | 1980 |
| Next Election: | 1992 United States Senate election in Missouri |
| Next Year: | 1992 |
| Election Date: | November 4, 1986 |
| Image1: | KitBond (1).jpg |
| Nominee1: | Kit Bond |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 777,612 |
| Percentage1: | 52.64% |
| Nominee2: | Harriett Woods |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 699,624 |
| Percentage2: | 47.36% |
| Map Size: | 275px |
| U.S. Senator | |
| Before Election: | Thomas Eagleton |
| Before Party: | Democratic Party (United States) |
| After Election: | Kit Bond |
| After Party: | Republican Party (United States) |
The 1986 United States Senate election in Missouri was held on November 4, 1986. Incumbent Democratic Senator Thomas Eagleton decided to retire instead of seeking a fourth term. Republican former Governor Kit Bond won the open seat. Kit Bond was the first Republican to win the Class 3 Senate seat in Missouri since 1944, and the first Republican to get over 50% of the vote for this seat since 1920. This was the only seat that Republicans flipped in 1986.