| Election Name: | 1980 United States Senate election in Indiana |
| Country: | Indiana |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1974 United States Senate election in Indiana |
| Previous Year: | 1974 |
| Next Election: | 1986 United States Senate election in Indiana |
| Next Year: | 1986 |
| Election Date: | November 4, 1980 |
| Image1: | Dan Quayle 1977.jpg |
| Nominee1: | Dan Quayle |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 1,182,414 |
| Percentage1: | 53.79% |
| Nominee2: | Birch Bayh |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 1,015,922 |
| Percentage2: | 46.21% |
| Map Size: | 250px |
| U.S. Senator | |
| Before Election: | Birch Bayh |
| Before Party: | Democratic Party (United States) |
| After Election: | Dan Quayle |
| After Party: | Republican Party (United States) |
The 1980 United States Senate election in Indiana took place on November 4, 1980, along with elections to the United States Senate in other states as well as the presidential election, elections to the United States House of Representatives and various state and local elections. Incumbent Democratic U.S. Senator Birch Bayh ran for a fourth term, but was defeated by Republican nominee, U.S. Representative Dan Quayle. Dan Quayle's swearing-in marked the first time since 1959 that Republicans held both United States Senate seats from Indiana.
Birch Bayh, the incumbent Senator, faced no opposition from Indiana and avoided a primary election. Bayh was originally elected in 1962 and re-elected in 1968 and 1974. He was Chairman of Senate Intelligence Committee and architect of 25th and 26th Amendments. This election was one of the key races in the country, and signaled a trend that would come to be known as Reagan's coattails, describing the influence Ronald Reagan had in congressional elections. Incumbent three-term Senator Birch Bayh was defeated by over 160,000 votes to Representative Dan Quayle, who would later go on to be Vice President of the United States. Birch's son Evan would be elected to this very same Senate seat 18 years later in 1998, after previously serving 2 terms as Governor.