| Election Name: | 1968 United States Senate election in Florida |
| Country: | Florida |
| Flag Year: | 1900 |
| Type: | presidential |
| Ongoing: | Yes |
| Previous Election: | 1962 United States Senate election in Florida |
| Previous Year: | 1962 |
| Next Election: | 1974 United States Senate election in Florida |
| Next Year: | 1974 |
| Election Date: | November 5, 1968 |
| Image1: | Edward J Gurney.jpg |
| Nominee1: | Edward Gurney |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 1,131,499 |
| Percentage1: | 55.90% |
| Nominee2: | LeRoy Collins |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 892,637 |
| Percentage2: | 44.10% |
| U.S. senator | |
| Before Election: | George Smathers |
| Before Party: | Democratic Party (US) |
| After Election: | Edward Gurney |
| After Party: | Republican Party (US) |
The 1968 Florida United States Senate election was marked by the election of the first Republican to the United States Senate from Florida since Reconstruction.
Democratic three-term incumbent George Smathers decided to not seek re-election. Popular former two-term Governor LeRoy Collins won the Democratic nomination by defeating State Attorney General Earl Faircloth, while Representative Edward J. Gurney became the Republican candidate.
Gurney was much less well-known than Collins, but he won by a margin of over 11%. It is possible that Richard Nixon's victory in the presidential race (including winning Florida) helped Gurney defeat Collins. Gurney was the first Republican elected to the Senate from Florida since 1872.