| Election Name: | 1946 United States Senate election in Florida |
| Country: | Florida |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1940 United States Senate election in Florida |
| Previous Year: | 1940 |
| Next Election: | 1952 United States Senate election in Florida |
| Next Year: | 1952 |
| Election Date: | November 5, 1946 |
| Image1: | Spessard Holland.JPG |
| Nominee1: | Spessard Holland |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 156,232 |
| Percentage1: | 78.65% |
| Nominee2: | J. Harry Schad |
| Party2: | Republican Party (US) |
| Popular Vote2: | 42,408 |
| Percentage2: | 21.35% |
| Map Size: | 280px |
| U.S. Senator | |
| Before Election: | Spessard Holland |
| Before Party: | Democratic Party (US) |
| After Election: | Spessard Holland |
| After Party: | Democratic Party (US) |
| Flag Year: | 1900 |
The 1946 United States Senate election in Florida was held on November 5, 1946.
Incumbent Florida Senator Charles O. Andrews did not run for re-election and died on September 18. Former Governor Spessard Holland, who served from 1941 to 1945, had already won the May Democratic primary (usually tantamount to victory in the solidly Democratic South), and was appointed to the vacant seat by Governor Millard Caldwell. Holland was then elected in the regular fall election.
Schad was unopposed for the Republican nomination.
On September 18, outgoing Senator Andrews died. Governor Millard Caldwell appointed Holland as Andrews' replacement for the remainder of the term, ending January 3, 1947.