The 1880 United States House of Representatives elections in South Carolina were held on November 2, 1880, to elect five representatives Representatives for two-year terms from the state of South Carolina. All five incumbents were re-elected and the composition of the state delegation remained solely Democratic.
Incumbent Democratic Congressman John S. Richardson of the 1st congressional district, in office since 1879, defeated Republican challenger Samuel J. Lee.
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Incumbent Democratic Congressman Michael P. O'Connor of the 2nd congressional district, in office since 1879, defeated Republican challenger Edmund W.M. Mackey.
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Incumbent Democratic Congressman D. Wyatt Aiken of the 3rd congressional district, in office since 1877, defeated Republican challenger C.J. Stollbrand.
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Incumbent Democratic Congressman John H. Evins of the 4th congressional district, in office since 1877, defeated Republican challenger A. Blythe.
|-| bgcolor="#0BDA51" || Greenback-Labor| J. Hendrix McLane| align="right" | 414| align="right" | 1.0| align="right" | +1.0|-|-| | colspan=5 |Democratic hold|-
Incumbent Democratic Congressman George D. Tillman of the 5th congressional district, in office since 1879, defeated Republican challenger Robert Smalls.
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