| District | Incumbent | Party | First elected | Result | Candidates | |||
|---|---|---|---|---|---|---|---|---|
| Thomas Lowndes | Federalist | 1800 | Incumbent retired. New member elected. Democratic-Republican gain. | nowrap | √ Robert Marion (Democratic-Republican) 60.6% Thomas L. Smith (Federalist) 37.0% Scattering 2.4% | |||
| William Butler Sr. | Democratic-Republican | 1800 | Incumbent re-elected. | nowrap | √ William Butler Sr. (Democratic-Republican) | |||
| Benjamin Huger | Federalist | 1798 | Incumbent retired. New member elected. Democratic-Republican gain. | nowrap | √ David R. Williams (Democratic-Republican) 58.0% Robert Witherspoon (Democratic-Republican) 29.0% Joseph Blyth (Democratic-Republican) 13.0% | |||
| Wade Hampton | Democratic-Republican | 1803 | Incumbent retired. New member elected. Democratic-Republican hold. | nowrap | √ O'Brien Smith (Democratic-Republican) John Taylor (Democratic-Republican) | |||
| Richard Winn | Democratic-Republican | 1802 (Special) | Incumbent re-elected. | nowrap | √ Richard Winn (Democratic-Republican) John Kershaw | |||
| Levi Casey | Democratic-Republican | 1803 | Incumbent re-elected. | nowrap | √ Levi Casey (Democratic-Republican) | |||
| Thomas Moore | Democratic-Republican | 1800 | Incumbent re-elected. | nowrap | √ Thomas Moore (Democratic-Republican) | |||
| John B. Earle | Democratic-Republican | 1803 | Incumbent re-elected but resigned March 3, 1805, triggering a special election. | nowrap | √ John B. Earle (Democratic-Republican) |