South Carolina increased its apportionment from 6 seats to 8 after the 1800 census.
| District | Incumbent | Party | First elected | Result | Candidates | |||
|---|---|---|---|---|---|---|---|---|
| Thomas Lowndes | Federalist | 1800 | Incumbent re-elected. | nowrap | √ Thomas Lowndes (Federalist) 52.3% Robert Marion (Democratic-Republican) 47.7% | |||
| John Rutledge Jr. | Federalist | 1796 | Incumbent lost re-election. New member elected. Democratic-Republican gain. | √ William Butler Sr. (Democratic-Republican) 93.3% John Rutledge Jr. (Federalist) 6.7% | ||||
| William Butler Sr. | Democratic-Republican | 1800 | Incumbent re-elected. | |||||
| Benjamin Huger | Federalist | 1798 | Incumbent re-elected. | nowrap | √ Benjamin Huger (Federalist) 50.9% Lemuel Benton (Democratic-Republican) 49.1% | |||
| None (District created) | New seat. New member elected. Democratic-Republican gain. | nowrap | √ Wade Hampton (Democratic-Republican) 50.9% John Taylor (Federalist) 49.1% | |||||
| Richard Winn | Democratic-Republican | 1802 (Special) | Incumbent re-elected. | nowrap | √ Richard Winn (Democratic-Republican) 52.1% John Kershaw (Federalist) 47.9% | |||
| None (District created) | New seat. New member elected. Democratic-Republican gain. | nowrap | √ Levi Casey (Democratic-Republican) 43.5% John Calhoun (Democratic-Republican) 29.8% Robert Creswell (Federalist) 14.1% James Saxon (Federalist) 10.3% Benjamin Herndon (Federalist) 2.4% | |||||
| Thomas Moore | Democratic-Republican | 1800 | Incumbent re-elected. | nowrap | √ Thomas Moore (Democratic-Republican) 60.5% William Hill (Federalist) 25.8% William Smith (Democratic-Republican) 13.8% | |||
| None (District created) | New seat. New member elected. Democratic-Republican gain. | nowrap | √ John B. Earle (Democratic-Republican) 71.8% Eliab Moore (Federalist) 28.2% | |||||