Kentucky elected its members August 6, 1810.
| District | Incumbent | This race | ||||||
|---|---|---|---|---|---|---|---|---|
| Representative | Party | First elected | Results | Candidates | ||||
| Matthew Lyon | Democratic-Republican | 1797 1803 | Incumbent lost re-election. New member elected. Democratic-Republican hold. | nowrap | √ Anthony New (Democratic-Republican) 60.3% Matthew Lyon (Democratic-Republican) 39.7% | |||
| Samuel McKee | Democratic-Republican | 1808 | Incumbent re-elected. | nowrap | √ Samuel McKee (Democratic-Republican) 100% | |||
| Henry Crist | Democratic-Republican | 1808 | Incumbent retired. New member elected. Democratic-Republican hold. | nowrap | √ Stephen Ormsby (Democratic-Republican) Philip Quinton | |||
| Richard M. Johnson | Democratic-Republican | 1806 | Incumbent re-elected. | nowrap | √ Richard M. Johnson (Democratic-Republican) John S. Hunter | |||
| Benjamin Howard | Democratic-Republican | 1806 | Incumbent resigned April 10, 1810 to become Governor of Louisiana Territory. New member elected. Democratic-Republican hold. Successor was not a candidate to finish the current term, see above. | nowrap | √ Henry Clay (Democratic-Republican) 100% | |||
| Joseph Desha | Democratic-Republican | 1806 | Incumbent re-elected. | nowrap | √ Joseph Desha (Democratic-Republican) 100% | |||