| Post: | Ambassador |
| Body: | the United States to Ghana |
| Insignia: | US Department of State official seal.svg |
| Insigniasize: | 120px |
| Insigniacaption: | Seal of the United States Department of State |
| Incumbent: | Virginia Palmer |
| Incumbentsince: | May 10, 2022 |
| Nominator: | The President of the United States |
| Appointer: | The President |
| Appointer Qualified: | with Senate advice and consent |
| Inaugural: | Donald W. Lamm as Chargé d'Affaires |
| Formation: | February 28, 1957 |
| Website: | U.S. Embassy - Accra |
The following is a list of ambassadors of the United States to Ghana. The embassy in Accra was established March 6, 1957, with Donald W. Lamm in charge as chargé d'affaires. President Joe Biden nominated career U.S. diplomat and Acting Assistant Secretary/Principal Deputy Assistant Secretary of the Bureau of Energy Resources Virginia E. Palmer for the position on June 2, 2021.
| Notes | |||||
| Donald W. Lamm[1] – Career FSO | Chargé d'Affaires | March 12, 1957 | April 19, 1957 | ||
| Peter Rutter[2] – Career FSO | April 25, 1957 | June 19, 1957 | |||
| Wilson C. Flake – Career FSO | Ambassador Extraordinary and Plenipotentiary | May 20, 1957 | June 19, 1957 | November 21, 1960 | Reaccredited when Ghana became a republic |
| Francis H. Russell[3] – Career FSO | November 11, 1960 | January 23, 1961 | March 13, 1962 | ||
| William P. Mahoney Jr. – Political appointee | May 21, 1962 | June 22, 1962 | May 26, 1965 | ||
| Franklin H. Williams – Political appointee | October 20, 1965 | January 17, 1966 | May 3, 1968 | Reaccredited after change of government | |
| Thomas W. McElhiney – Career FSO | July 24, 1968 | September 14, 1968 | May 29, 1971 | ||
| Fred L. Hadsel – Career FSO | July 23, 1971 | September 25, 1971 | July 29, 1974 | ||
| Shirley Temple Black – Political appointee | September 19, 1974 | December 6, 1974 | July 13, 1976 | ||
| Robert P. Smith – Career FSO | October 4, 1976 | December 17, 1976 | May 7, 1979 | ||
| Thomas W. M. Smith – Career FSO | September 28, 1979 | December 12, 1979 | July 2, 1983 | ||
| Robert E. Fritts – Career FSO | July 6, 1983 | July 28, 1983 | June 2, 1986 | ||
| Stephen R. Lyne[4] – Career FSO | March 27, 1987 | July 11, 1987 | September 9, 1989 | ||
| Raymond Charles Ewing – Career FSO | August 7, 1989 | November 9, 1989 | August 14, 1992 | ||
| Kenneth Lee Brown – Career FSO | July 14, 1992 | September 24, 1992 | July 19, 1995 | ||
| Edward P. Brynn – Career FSO | October 3, 1995 | December 19, 1995 | July 10, 1998 | ||
| Kathryn Dee Robinson – Career FSO | October 22, 1998 | December 16, 1998 | September 1, 2001 | ||
| Nancy Jo Powell – Career FSO | July 16, 2001 | September 14, 2001 | May 26, 2002 | ||
| Mary Carlin Yates – Career FSO | November 26, 2002 | January 28, 2003 | July 25, 2005 | ||
| Pamela E. Bridgewater – Career FSO | June 21, 2005 | October 11, 2005 | June 10, 2008 | ||
| Donald G. Teitelbaum – Career FSO | June 6, 2008 | September 9, 2008 | August 24, 2012[5] | ||
| Gene A. Cretz – Career FSO | April 11, 2012 | October 8, 2012 | June 26, 2015 | ||
| Robert P. Jackson – Career FSO | November 22, 2015 | February 4, 2016 | July 27, 2018 | ||
| Stephanie S. Sullivan – Career FSO | September 10, 2018 | January 23, 2019 | April 8, 2022[6] | ||
| Virginia Palmer – Career FSO | March 2, 2022 | May 10, 2022 | Incumbent |
Senior Staff Of Travel Relations Peter Asante Smith