| Post: | Ambassador |
| Body: | the United States to Eritrea |
| Insignia: | US Department of State official seal.svg |
| Insigniasize: | 120px |
| Insigniacaption: | Seal of the United States Department of State |
| Incumbent: | Leslie Freriksen as Chargé d'Affaires ad interim[1] |
| Incumbentsince: | July 18, 2022 |
| Nominator: | The President of the United States |
| Appointer: | The President |
| Appointer Qualified: | with Senate advice and consent |
| Inaugural: | Joseph P. O'Neill as Chargé d'Affaires ad interim |
| Formation: | June 11, 1991 |
| Website: | U.S. Embassy - Asmara |
The following is a list of United States ambassadors to Eritrea. The United States recognized Eritrea's independence April 27, 1991, and established diplomatic relations on June 11, 1991. The Consulate in Asmara then became an Embassy with Joseph P. O'Neill as Chargé d'Affaires ad interim. The U.S. embassy in Eritrea has been represented by a Chargé d'Affaires since 2010.
| Robert Gordon Houdek - Career FSO | Ambassador Extraordinary and Plenipotentiary | November 22, 1993 | December 31, 1993 | Left post, September 10, 1996 | ||
| John F. Hicks - Career FSO | Ambassador Extraordinary and Plenipotentiary | July 2, 1996 | September 29, 1996 | Left post, May 11, 1997 | ||
| William Davis Clarke - Career FSO | Ambassador Extraordinary and Plenipotentiary | June 29, 1998 | August 20, 1998 | August 12, 2001 | ||
| Donald J. McConnell - Career FSO | Ambassador Extraordinary and Plenipotentiary | July 16, 2001 | October 3, 2001 | Left post, July 16, 2004 | ||
| Scott H. DeLisi - Career FSO | Ambassador Extraordinary and Plenipotentiary | May 12, 2004 | October 21, 2004 | Left post, June 2, 2007 | ||
| Ronald K. McMullen - Career FSO | Ambassador Extraordinary and Plenipotentiary | October 29, 2007 | N/A | July 19, 2010 | ||
| Joel Reifman - Career FSO | Chargé d'Affaires ad interim | July 19, 2010 | N/A | February 2012 | ||
| Sue Bremner - Career FSO | Chargé d'Affaires ad interim | July 2012 | N/A | April 2014 | ||
| Louis Mazel - Career FSO | Chargé d'Affaires | July 2014 | N/A | July 27, 2016 | ||
| Natalie E. Brown - Career FSO | Chargé d'Affaires | September 23, 2016 | N/A | November 25, 2019 | ||
| Steven C. Walker - Career FSO[2] | Chargé d'Affaires | December 12, 2019 | N/A | July 17, 2022[3] | ||
| Leslie Freriksen - Career FSO | Chargé d'Affaires | July 18, 2022 | N/A | Incumbent |