| Post: | Ambassador |
| Body: | the United States to Cameroon |
| Insignia: | US Department of State official seal.svg |
| Insigniasize: | 120 |
| Insigniacaption: | Seal of the United States Department of State |
| Incumbent: | Christopher J. Lamora |
| Incumbentsince: | March 21, 2022 |
| Nominator: | The President of the United States |
| Appointer: | The President |
| Appointer Qualified: | with Senate advice and consent |
| Inaugural: | Bolard More as Chargé d'Affaires ad interim |
| Formation: | January 1, 1960 |
This is a list of ambassadors from the United States to Cameroon. The American Embassy at Yaounde was established on January 1, 1960, with Bolard More as Chargé d'Affaires ad interim.
| Name | Title | Appointed | Presented credentials | Terminated mission | Notes |
|---|---|---|---|---|---|
| Leland Barrows – Career FSO | Ambassador Extraordinary and Plenipotentiary | April 20, 1960 | June 9, 1960 | September 6, 1966 | Accredited also to Togo and resident at Yaounde. |
| Robert L. Payton – Political appointee | January 26, 1967 | March 4, 1967 | May 27, 1969 | ||
| Lewis Hoffacker – Career FSO | December 2, 1969 | December 20, 1969 | June 6, 1972 | Also accredited to Equatorial Guinea and resident at Yaounde. | |
| C. Robert Moore – Career FSO | June 27, 1972 | July 22, 1972 | July 28, 1975 | Also accredited to Equatorial Guinea and resident at Yaounde. | |
| Herbert J. Spiro – Political appointee | July 24, 1975 | September 1, 1975 | May 7, 1977 | Accredited also to Equatorial Guinea until Mar 14, 1976; resident at Yaounde. | |
| Mabel M. Smythe – Political appointee | May 11, 1977 | October 1, 1977 | February 24, 1980 | Also accredited to Equatorial Guinea | |
| Hume A. Horan – Career FSO | June 30, 1980 | July 29, 1980 | May 17, 1983 | Also accredited to Equatorial Guinea until September 29, 1981 | |
| Myles Robert Rene Frechette – Career FSO | May 26, 1983 | September 8, 1983 | July 30, 1987 | ||
| Mark L. Edelman – Political appointee | July 31, 1987 | September 9, 1987 | March 19, 1989 | ||
| Frances D. Cook – Career FSO | November 21, 1989 | December 21, 1989 | January 1, 1993 | ||
| Harriet Winsar Isom – Career FSO | August 17, 1992 | January 19, 1993 | January 17, 1996 | ||
| Charles H. Twining – Career FSO | December 19, 1995 | February 28, 1996 | August 17, 1998 | Also Accredited to Equatorial Guinea and resident at Yaounde. | |
| John Melvin Yates – Career FSO | October 22, 1998 | January 5, 1999 | November 4, 2001 | Also Accredited to Equatorial Guinea and resident at Yaounde. | |
| George McDade Staples – Career FSO | September 5, 2001 | December 21, 2001 | July 10, 2004 | Also accredited to Equatorial Guinea; resident at Yaounde. | |
| R. Niels Marquardt – Career FSO | July 2, 2004 | October 29, 2004 | April 9, 2007 | Also accredited to Equatorial Guinea; resident at Yaounde. | |
| Janet E. Garvey – Career FSO | May 30, 2007 | November 9, 2007 | August 1, 2010 | Also accredited to Equatorial Guinea; resident at Yaounde. | |
| Robert P. Jackson – Career FSO | September 17, 2010 | October 12, 2010 | October 5, 2013 | ||
| Michael Hoza – Career FSO | July 31, 2014 | August 22, 2014 | September 11, 2017 | ||
| Peter Barlerin – Career FSO | November 2, 2017 | December 20, 2017 | July 16, 2020 | ||
| Christopher J. Lamora – Career FSO | December 18, 2021 | March 21, 2022 | Incumbent |