Ungeremine Explained

Ungeremine is a betaine-type alkaloid isolated from Nerine bowdenii[1] and related plants such as Pancratium maritimum.[2] Pharmacologically, it is of interest as an acetylcholinesterase inhibitor and accordingly as possibly relevant to Alzheimer's disease.[3] It also has been investigated as a bactericide.[2]

Notes and References

  1. 15516727 . 2004 . Rhee . I. K. . Isolation of the acetylcholinesterase inhibitor ungeremine from Nerine bowdenii by preparative HPLC coupled on-line to a flow assay system . Biological & Pharmaceutical Bulletin . 27 . 11 . 1804–9 . Appels . N . Hofte . B . Karabatak . B . Erkelens . C . Stark . L. M. . Flippin . L. A. . Verpoorte . R . 10.1248/bpb.27.1804. free .
  2. 10.1021/jf304586j. 23331165. Ungeremine and Its Hemisynthesized Analogues as Bactericides against Flavobacterium columnare. Journal of Agricultural and Food Chemistry. 61. 6. 1179–83. 2013. Schrader. Kevin K.. Avolio. Fabiana. Andolfi. Anna. Cimmino. Alessio. Evidente. Antonio.
  3. 10.2174/1570159X11311040004. 24381530. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer's Disease Therapy. Current Neuropharmacology. 11. 4. 388–413. 2013. Murray. Ana. Faraoni. Maria. Castro. María. Alza. Natalia. Cavallaro. Valeria. 3744903.

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