Uncoupling (neuropsychopharmacology) explained

In neuropsychopharmacology, uncoupling, also known as decoupling, is the process of receptor- or ligand-binding sites or domains becoming separated, moving alignments and/or becoming internalised as a result of drug tolerance resulting from prolonged exposure to bioavailable psychoactive substances or toxins.^{[1] [2]}

Notes and References

1. Mize . Amy L . Alpher . Richard H . Rapid uncoupling of serotonin-1A receptors in rat hippocampus by 17(beta)-estradiol in vitro requires protein kinases A and C . Neuroendocrinology . . ProQuest.
2. Ganguly . Prabarna . Holland . Freedom H . Brenhouse . Heather C . Functional Uncoupling NMDAR NR2A Subunit from PSD-95 in the Prefrontal Cortex: Effects on Behavioral Dysfunction and Parvalbumin Loss after Early-Life Stress . Neuropsychopharmacology. .