Ubiquitin carboxyl-terminal hydrolase L5 explained

Ubiquitin carboxyl-terminal hydrolase isozyme L5 is an enzyme that in humans is encoded by the UCHL5 gene.^{[1] [2] [3]}

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Hu RM, Han ZG, Song HD, etal . Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 17 . 9543–8 . 2000 . 10931946 . 16901 . 10.1073/pnas.160270997 . 2000PNAS...97.9543H . free .
• Li T, Duan W, Yang H, etal . Identification of two proteins, S14 and UIP1, that interact with UCH37. . FEBS Lett. . 488 . 3 . 201–5 . 2001 . 11163772 . 10.1016/S0014-5793(00)02436-4 . 10536/DRO/DU:30009147 . 40717095 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Rolén U, Kobzeva V, Gasparjan N, etal . Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines. . Mol. Carcinog. . 45 . 4 . 260–9 . 2006 . 16402389 . 10.1002/mc.20177 . 6633207 .
• Gandhi TK, Zhong J, Mathivanan S, etal . Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets. . Nat. Genet. . 38 . 3 . 285–93 . 2006 . 16501559 . 10.1038/ng1747 . 1446423 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Yao T, Song L, Xu W, etal . Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. . Nat. Cell Biol. . 8 . 9 . 994–1002 . 2006 . 16906146 . 10.1038/ncb1460 . 25308728 .
• Hamazaki J, Iemura S, Natsume T, etal . A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. . EMBO J. . 25 . 19 . 4524–36 . 2006 . 16990800 . 1589993 . 10.1038/sj.emboj.7601338 .
• Qiu XB, Ouyang SY, Li CJ, etal . hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. . EMBO J. . 25 . 24 . 5742–53 . 2007 . 17139257 . 1698896 . 10.1038/sj.emboj.7601450 .

Notes and References

1. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics . Genome Res . 10 . 5 . 703–13 . Aug 2000 . 10810093 . 310876 . 10.1101/gr.10.5.703 .
2. Wicks SJ, Haros K, Maillard M, Song L, Cohen RE, Dijke PT, Chantry A . The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling . Oncogene . 24 . 54 . 8080–4 . Dec 2005 . 16027725 . 10.1038/sj.onc.1208944 . free .
3. Web site: Entrez Gene: UCHL5 ubiquitin carboxyl-terminal hydrolase L5.