Ubiquitin-fold modifier conjugating enzyme 1 explained
Ubiquitin-fold modifier conjugating enzyme 1 is a protein that in humans is encoded by the UFC1 gene.[1]
Function
UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008].
Further reading
- Komatsu M, Chiba T, Tatsumi K, Iemura S, Tanida I, Okazaki N, Ueno T, Kominami E, Natsume T, Tanaka K . A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier . EMBO J. . 23 . 9 . 1977–86 . May 2004 . 15071506 . 404325 . 10.1038/sj.emboj.7600205 .
- Liu G, Forouhar F, Eletsky A, Atreya HS, Aramini JM, Xiao R, Huang YJ, Abashidze M, Seetharaman J, Liu J, Rost B, Acton T, Montelione GT, Hunt JF, Szyperski T . NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway . J. Struct. Funct. Genomics . 10 . 2 . 127–36 . April 2009 . 19101823 . 2850604 . 10.1007/s10969-008-9054-7 .
- Homrich M, Wobst H, Laurini C, Sabrowski J, Schmitz B, Diestel S . Cytoplasmic domain of NCAM140 interacts with ubiquitin-fold modifier-conjugating enzyme-1 (Ufc1) . Exp. Cell Res. . 324 . 2 . 192–9 . June 2014 . 24726913 . 10.1016/j.yexcr.2014.04.003 .
- Xie S . Characterization, crystallization and preliminary X-ray crystallographic analysis of the human Uba5 C-terminus-Ufc1 complex . Acta Crystallogr F . 70 . Pt 8 . 1093–7 . August 2014 . 25084390 . 4118812 . 10.1107/S2053230X14014502 .
- Tellermann A, Witte T, Lansche C, Stoll M, Schmidt RE, Baerlecken NT . Autoantibodies binding to ubiquitin-fold modifier-conjugating enzyme 1 (Ufc1) and pleckstrin homology domain containing, family G (with RhoGef domain) member 2 (Plekhg2) are associated with mycobacterial infections . HIV Med. . 16 . 2 . 114–21 . February 2015 . 25213431 . 10.1111/hiv.12194 . free .
- Cao C, Sun J, Zhang D, Guo X, Xie L, Li X, Wu D, Liu L . The long intergenic noncoding RNA UFC1, a target of MicroRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of β-catenin in HCC cells . Gastroenterology . 148 . 2 . 415–26.e18 . February 2015 . 25449213 . 10.1053/j.gastro.2014.10.012 .
- Zhang G, Wu Y, Xu D, Yan X . Long Noncoding RNA UFC1 Promotes Proliferation of Chondrocyte in Osteoarthritis by Acting as a Sponge for miR-34a . DNA Cell Biol. . 35 . 11 . 691–695 . November 2016 . 27529373 . 10.1089/dna.2016.3397 .
Notes and References
- Web site: Entrez Gene: Ubiquitin-fold modifier conjugating enzyme 1. 2020-04-15.
