UVRAG explained

UV radiation resistance-associated gene protein is a protein that in humans is encoded by the UVRAG gene.^{[1] [2]}

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells.

Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.

Further reading

• Liang C . UVRAG: a new player in autophagy and tumor cell growth . Autophagy . 3 . 1 . 69–71 . 2007 . 17106237 . 10.4161/auto.3437. Feng P . Ku B . 3 . Oh . BH . Jung . JU . free.
• Teitz T . Isolation by polymerase chain reaction of a cDNA whose product partially complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells . Gene . 87 . 2 . 295–298 . 1990 . 2332174 . 10.1016/0378-1119(90)90316-J . Penner M . Eli D . 3 . Stark . Merav . Bakhanashvili . Mary . Naiman . Tova . Canaani . Dan .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . A . Sugano . S .
• Bekri S . Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma . Cytogenet. Cell Genet. . 79 . 1–2 . 125–131 . 1998 . 9533029 . 10.1159/000134699 . Adélaïde J . Merscher S . 3 . Grosgeorge . J. . Caroli-Bosc . F. . Perucca-Lostanlen . D.P. . Kelley . P.M. . pÉBusque . M.-J. . Theillet . C. .
• Iida A . Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation . Hum. Genet. . 106 . 3 . 277–287 . 2000 . 10798355 . 10.1007/s004390051038 . Emi M . Matsuoka R . 3 . Hiratsuka . E. . Okui . K. . Ohashi . H. . Inazawa . J. . Fukushima . Y. . Imai . T. . 1 November 2024 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Goi T . Ascending colon cancer with hepatic metastasis and cholecystolithiasis in a patient with situs inversus totalis without any expression of UVRAG mRNA: report of a case . Surg. Today . 33 . 9 . 702–706 . 2004 . 12928850 . 10.1007/s00595-002-2567-y . Kawasaki M . Yamazaki T . 3 . Koneri . Kenji . Katayama . Kanji . Hirose . Kazuo . Yamaguchi . Akio . 29935419 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Ionov Y . Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability . Oncogene . 23 . 3 . 639–645 . 2004 . 14737099 . 10.1038/sj.onc.1207178 . Nowak N . Perucho M . 3 . Markowitz . Sanford . Cowell . John K . 22875014 .
• Kimura K . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . Wakamatsu A . Suzuki Y . 3 . Ota . T . Nishikawa . T . Yamashita . R . Yamamoto . J . Sekine . M . Tsuritani . K .
• Liang C . Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG . Nat. Cell Biol. . 8 . 7 . 688–698 . 2006 . 16799551 . 10.1038/ncb1426 . Feng P . Ku B . 3 . Dotan . Iris . Canaani . Dan . Oh . Byung-Ha . Jung . Jae U. . 19739498 .

Notes and References

1. Perelman B, Dafni N, Naiman T, Eli D, Yaakov M, Feng TL, Sinha S, Weber G, Khodaei S, Sancar A, Dotan I, Canaani D . Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus . Genomics . 41 . 3 . 397–405 . Jul 1997 . 9169138 . 10.1006/geno.1997.4623 . free .
2. Web site: Entrez Gene: UVRAG UV radiation resistance associated gene.