UTY (gene) explained

Histone demethylase UTY is an enzyme that in humans is encoded by the UTY gene.^{[1] [2] [3]}

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein–protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms.

Interactions

UTY has been shown to interact with TLE1^[4] and WDR90.^[5]

Further reading

• Lahn BT, Page DC . Functional coherence of the human Y chromosome . Science . 278 . 5338 . 675–80 . October 1997 . 9381176 . 10.1126/science.278.5338.675 . 1997Sci...278..675L .
• Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S . Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms . The Biochemical Journal . 337 (Pt 1) . 1 . 13–7 . January 1999 . 9854018 . 1219929 . 10.1042/0264-6021:3370013 .
• Warren EH, Gavin MA, Simpson E, Chandler P, Page DC, Disteche C, Stankey KA, Greenberg PD, Riddell SR . 6 . The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen . Journal of Immunology . 164 . 5 . 2807–14 . March 2000 . 10679124 . 10.4049/jimmunol.164.5.2807 . free .
• Foresta C, Ferlin A, Moro E . Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility . Human Molecular Genetics . 9 . 8 . 1161–9 . May 2000 . 10767340 . 10.1093/hmg/9.8.1161 .
• Shen P, Wang F, Underhill PA, Franco C, Yang WH, Roxas A, Sung R, Lin AA, Hyman RW, Vollrath D, Davis RW, Cavalli-Sforza LL, Oefner PJ . 6 . Population genetic implications from sequence variation in four Y chromosome genes . Proceedings of the National Academy of Sciences of the United States of America . 97 . 13 . 7354–9 . June 2000 . 10861003 . 16549 . 10.1073/pnas.97.13.7354 . 2000PNAS...97.7354S . free .
• Vogt MH, Goulmy E, Kloosterboer FM, Blokland E, de Paus RA, Willemze R, Falkenburg JH . UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition . Blood . 96 . 9 . 3126–32 . November 2000 . 10.1182/blood.V96.9.3126 . 11049993 .
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nature Biotechnology . 21 . 5 . 566–9 . May 2003 . 12665801 . 10.1038/nbt810 . 23783563 .
• Agate RJ, Choe M, Arnold AP . Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches . Molecular Biology and Evolution . 21 . 2 . 384–96 . February 2004 . 14660691 . 10.1093/molbev/msh027 . free .
• Gerrard DT, Filatov DA . Positive and negative selection on mammalian Y chromosomes . Molecular Biology and Evolution . 22 . 6 . 1423–32 . June 2005 . 15758204 . 10.1093/molbev/msi128 . free .

Notes and References

1. Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, Simpson E, Koopman P . 6 . An H-YDb epitope is encoded by a novel mouse Y chromosome gene . Nature Genetics . 14 . 4 . 474–8 . December 1996 . 8944031 . 10.1038/ng1296-474 . 9994966 .
2. Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, Steiner K, Tam PP, Monaco AP, Willard HF, Koopman P . 6 . The UTX gene escapes X inactivation in mice and humans . Human Molecular Genetics . 7 . 4 . 737–42 . April 1998 . 9499428 . 10.1093/hmg/7.4.737 . free .
3. Web site: Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked.
4. Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S . Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms . The Biochemical Journal . 337 (Pt 1) . 1 . 13–7 . January 1999 . 9854018 . 1219929 . 10.1042/0264-6021:3370013 .
5. Web site: STRING: functional protein association networks. string-db.org. 2015-05-07.