UTX (gene) explained

Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), is a protein which in humans is encoded by the KDM6A gene.^{[1] [2] [3]} It belongs to the 2-oxoglutarate (2OG)-dependent dioxygenase superfamily.

Function

UTX has been linked with demethylation of lysine residues on histone, in particular H3K27, resulting in a gene de-repression, a potential means of regulating cellular metabolism.^[4]

Further reading

• Lahn BT, Page DC . Functional coherence of the human Y chromosome . Science . 278 . 5338 . 675–80 . 1997 . 9381176 . 10.1126/science.278.5338.675 . 1997Sci...278..675L .
• Greenfield A, Carrel L, Pennisi D, etal . The UTX gene escapes X inactivation in mice and humans . Hum. Mol. Genet. . 7 . 4 . 737–42 . 1998 . 9499428 . 10.1093/hmg/7.4.737 . free .
• Grbavec D, Lo R, Liu Y, etal . Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms . Biochem. J. . 337 (Pt 1) . Pt 1. 13–7 . 1999 . 9854018 . 10.1042/0264-6021:3370013 . 1219929 .
• Foresta C, Ferlin A, Moro E . Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility . Hum. Mol. Genet. . 9 . 8 . 1161–9 . 2000 . 10767340 . 10.1093/hmg/9.8.1161 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Agate RJ, Choe M, Arnold AP . Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches . Mol. Biol. Evol. . 21 . 2 . 384–96 . 2004 . 14660691 . 10.1093/molbev/msh027 . free .
• Colland F, Jacq X, Trouplin V, etal . Functional Proteomics Mapping of a Human Signaling Pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Ballif BA, Villén J, Beausoleil SA, etal . Phosphoproteomic analysis of the developing mouse brain . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2005 . 15345747 . 10.1074/mcp.M400085-MCP200 . free .
• Gerrard DT, Filatov DA . Positive and negative selection on mammalian Y chromosomes . Mol. Biol. Evol. . 22 . 6 . 1423–32 . 2005 . 15758204 . 10.1093/molbev/msi128 . free .
• Cho YW, Hong T, Hong S, etal . PTIP Associates with MLL3- and MLL4-containing Histone H3 Lysine 4 Methyltransferase Complex . J. Biol. Chem. . 282 . 28 . 20395–406 . 2007 . 17500065 . 10.1074/jbc.M701574200 . 2729684 . free .
• Agger K, Cloos PA, Christensen J, etal . UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development . Nature . 449 . 7163 . 731–4 . 2007 . 17713478 . 10.1038/nature06145 . 2007Natur.449..731A . 4413812 .
• Lee MG, Villa R, Trojer P, etal . Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination . Science . 318 . 5849 . 447–50 . 2007 . 17761849 . 10.1126/science.1149042 . 2007Sci...318..447L . 23883131 . free .
• Lan F, Bayliss PE, Rinn JL, etal . A histone H3 lysine 27 demethylase regulates animal posterior development . Nature . 449 . 7163 . 689–94 . 2007 . 17851529 . 10.1038/nature06192 . 2007Natur.449..689L . 612144 .
• Hong S, Cho YW, Yu LR, etal . Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases . Proc. Natl. Acad. Sci. U.S.A. . 104 . 47 . 18439–44 . 2008 . 18003914 . 10.1073/pnas.0707292104 . 2141795 . free . 2007PNAS..10418439H .

Notes and References

1. Web site: Entrez Gene: KDM6A lysine demethylase 6A .
2. Lahn BT, Page DC . Functional coherence of the human Y chromosome . Science . 278 . 5338 . 675–80 . October 1997 . 9381176 . 10.1126/science.278.5338.675 . 1997Sci...278..675L .
3. Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, Steiner K, Tam PP, Monaco AP, Willard HF, Koopman P . The UTX gene escapes X inactivation in mice and humans . Hum. Mol. Genet. . 7 . 4 . 737–42 . April 1998 . 9499428 . 10.1093/hmg/7.4.737 . free .
4. Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R . Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination . Science . 318 . 5849 . 447–50 . October 2007 . 17761849 . 10.1126/science.1149042 . 2007Sci...318..447L . 23883131 . free .