The hospital ship was in constant service during the Spanish–American War, returning wounded and ill servicemen from Cuba to Norfolk, New York, and Boston. In February 1899, she sailed for Europe, and she visited ports there, in the Near East, the Far East, and Hawaii, before arriving at Mare Island, California, on 27 May, for an overhaul. She returned to sea on 1 July 1899 and, until October 1905, carried mail, passengers, and provisions from San Francisco to Hawaii, Guam, the Philippine Islands, China, and Japan. Solace was placed out of commission at the Mare Island Navy Yard on 12 October 1905.
Recommissioned on 3 June 1908, Solace voyaged to the Fiji Islands; Samoa; and Magdalena Bay, Mexico, before transiting the Panama Canal, calling at Caribbean ports, and steaming to Charleston, South Carolina, Solace was decommissioned there on 14 April 1909.
Recommissioned again on 20 November 1909, Solace joined the Atlantic Fleet on 6 December 1909 and served as a hospital ship at ports along the eastern seaboard of the United States from Newport, Rhode Island, to Key West, Florida. She was under the command of Luther Lochman von Wedekind. On 2 December 1910 she suffered minor damage in a collision with a barge near the Brooklyn Bridge, New York City.[1] She also operated at Guantanamo Bay, Cuba; in the Panama Canal Zone; and at other ports in the Caribbean. This routine was broken in October and November 1913 by a five-week voyage to France.
She was stationed in New York Harbor at the 82nd Street Landing in late December 1918.
On 1 January 1919, Solace was ordered to proceed to the vicinity of, then aground off Fire Island, New York, loaded with wounded veterans returning from France. Solace anchored off Fire Island that night. The next day, heavy seas prevented the transfer of survivors from Northern Pacific to the hospital ship. The seas subsided on the 3rd, and small boats began the transfer. Patients were taken on board all of that day and by the time Solace was ready to return to New York on the 4th, she had a total of 504 patients on board even though her berthing facilities could accommodate only about 200. These were used for the seriously wounded while the remainder were put in cots. Solace returned to Hoboken, New Jersey, that night; and, by 0530 on 5 January, had debarked all of the patients.
After her detachment from the Atlantic Fleet on 1 April 1921, Solace was berthed at the Philadelphia Navy Yard. She was decommissioned on 20 July 1921; struck from the Navy List on 6 August 1930; and sold to Boston Metals Co., Baltimore, Maryland, on 6 November for scrap.