USS Flusser (DD–20) was a in the United States Navy during World War I. She was the second ship named for Lieutenant commander Charles W. Flusser.
Flusser was launched on 20 July 1909, by Bath Iron Works, Bath, Maine, sponsored by Miss Genevieve Virden, grandniece of Commander Flusser; and commissioned on 28 October 1909.
Flusser arrived at Charleston, South Carolina - her home port - on 17 December 1909, and began her participation in the regular operating schedule of the Atlantic Torpedo Fleet, an organization many times redesignated in the years that followed. She cruised from the Caribbean to the coast of New England until August 1916, when she began neutrality patrols off New York and in Long Island Sound.
After a repair period at New Orleans, Louisiana early in 1917, Flusser had escort duty on the east coast until 30 July 1917, when she departed Charleston for two months of ocean escort and patrol duty based on Ponta Delgada, Azores. She had similar duty out of Brest, France, operating across the English Channel from 22 October-9 December 1918, returning to Charleston on 31 December. She was decommissioned at Philadelphia, Pennsylvania on 14 July 1919, and sold on 21 November.