USP48 explained

Ubiquitin carboxyl-terminal hydrolase 48 is an enzyme that in humans is encoded by the USP48 gene.^{[1] [2]}

This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[2]

In melanocytic cells USP48 gene expression may be regulated by MITF.^[3]

Further reading

• Wilkinson KD . Regulation of ubiquitin-dependent processes by deubiquitinating enzymes. . FASEB J. . 11 . 14 . 1245–56 . 1998 . 9409543 . 10.1096/fasebj.11.14.9409543. free . 11788220 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, etal . Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. . Biochem. Biophys. Res. Commun. . 314 . 1 . 54–62 . 2004 . 14715245 . 10.1016/j.bbrc.2003.12.050 .
• Suzuki Y, Yamashita R, Shirota M, etal . Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 .
• Lockhart PJ, Hulihan M, Lincoln S, etal . Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis. . DNA Seq. . 15 . 1 . 9–14 . 2004 . 15354349 . 10.1080/10855660310001638197. 36992328 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Tzimas C, Michailidou G, Arsenakis M, etal . Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB. . Cell. Signal. . 18 . 1 . 83–92 . 2006 . 16214042 . 10.1016/j.cellsig.2005.03.017 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C . Human and mouse proteases: a comparative genomic approach . Nat Rev Genet . 4 . 7 . 544–58 . Jul 2003 . 12838346 . 10.1038/nrg1111 . 2856065 .
2. Web site: Entrez Gene: USP48 ubiquitin specific peptidase 48.
3. Hoek KS, Schlegel NC, Eichhoff OM, et al. . Novel MITF targets identified using a two-step DNA microarray strategy . Pigment Cell Melanoma Res. . 21 . 6 . 665–76 . 2008 . 19067971 . 10.1111/j.1755-148X.2008.00505.x . free .