USP33 explained

Ubiquitin carboxyl-terminal hydrolase 33 is an enzyme that in humans is encoded by the USP33 gene.^{[1] [2]}

Interactions

USP33 has been shown to interact with DIO2,^[3] SELENBP1^[4] and Von Hippel–Lindau tumor suppressor.^[5]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 6 . 3 . 197–205 . 1999 . 10470851 . 10.1093/dnares/6.3.197 . free .
• Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G . Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein . J. Biol. Chem. . 277 . 7 . 4656–4662 . 2002 . 11739384 . 10.1074/jbc.M108269200 . free .
• Li Z, Wang D, Na X, Schoen SR, Messing EM, Wu G . Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor . Biochem. Biophys. Res. Commun. . 294 . 3 . 700–709 . 2002 . 12056827 . 10.1016/S0006-291X(02)00534-X .
• Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC . Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation . J. Clin. Invest. . 112 . 2 . 189–196 . 2003 . 12865408 . 164294 . 10.1172/JCI18348 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Allen MD, Bycroft M . The solution structure of the ZnF UBP domain of USP33/VDU1 . Protein Sci. . 16 . 9 . 2072–2075 . 2007 . 17766394 . 2206988 . 10.1110/ps.072967807 .

Notes and References

1. Puente XS, Sánchez LM, Overall CM, López-Otín C . Human and mouse proteases: a comparative genomic approach . Nat Rev Genet . 4 . 7 . 544–558 . Jul 2003 . 12838346 . 10.1038/nrg1111 . 2856065 .
2. Web site: Entrez Gene: USP33 ubiquitin specific peptidase 33.
3. Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC . Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation . J. Clin. Invest. . 112 . 2 . 189–196 . Jul 2003 . 12865408 . 164294 . 10.1172/JCI18348 .
4. Jeong JY, Wang Y, Sytkowski AJ . Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner . Biochem. Biophys. Res. Commun. . 379 . 2 . 583–588 . Feb 2009 . 19118533 . 10.1016/j.bbrc.2008.12.110 .
5. Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G . Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein . J. Biol. Chem. . 277 . 7 . 4656–4662 . Feb 2002 . 11739384 . 10.1074/jbc.M108269200 . free .