USP22 explained

Ubiquitin specific peptidase 22 is a protein that in humans is encoded by the USP22 gene on chromosome 17.^[1] USP22 is known to function as a histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA.^[2]

Further reading

• Lang G, Bonnet J, Umlauf D, Karmodiya K, Koffler J, Stierle M, Devys D, Tora L . The tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elements . Molecular and Cellular Biology . 31 . 18 . 3734–44 . September 2011 . 21746879 . 3165722 . 10.1128/MCB.05231-11 .
• Wang YL, Faiola F, Xu M, Pan S, Martinez E . Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein . The Journal of Biological Chemistry . 283 . 49 . 33808–15 . December 2008 . 18838386 . 2590711 . 10.1074/jbc.M806936200 . free .
• Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA . A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex . Molecular and Cellular Biology . 33 . 8 . 1487–502 . April 2013 . 23382074 . 3624249 . 10.1128/MCB.00971-12 .
• Zhang Y, Yao L, Zhang X, Ji H, Wang L, Sun S, Pang D . Elevated expression of USP22 in correlation with poor prognosis in patients with invasive breast cancer . Journal of Cancer Research and Clinical Oncology . 137 . 8 . 1245–53 . August 2011 . 21691749 . 10.1007/s00432-011-0998-9 . 9026376 .
• Ling SB, Sun DG, Tang B, Guo C, Zhang Y, Liang R, Wang LM . Knock-down of USP22 by small interfering RNA interference inhibits HepG2 cell proliferation and induces cell cycle arrest . Cellular and Molecular Biology . 58 Suppl . OL1803-8 . December 2012 . 23217440 .
• Xiong J, Che X, Li X, Yu H, Gong Z, Li W . Cloning and characterization of the human USP22 gene promoter . PLOS ONE . 7 . 12 . e52716 . 2012 . 23300749 . 3530469 . 10.1371/journal.pone.0052716 . 2012PLoSO...752716X . Semsey . Szabolcs . free .
• Glinsky GV, Berezovska O, Glinskii AB . Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer . The Journal of Clinical Investigation . 115 . 6 . 1503–21 . June 2005 . 15931389 . 1136989 . 10.1172/JCI23412 .
• Xu H, Liu YL, Yang YM, Dong XS . Knock-down of ubiquitin-specific protease 22 by micro-RNA interference inhibits colorectal cancer growth . International Journal of Colorectal Disease . 27 . 1 . 21–30 . January 2012 . 21773699 . 10.1007/s00384-011-1275-8 . 25987858 .
• Liu YL, Yang YM, Xu H, Dong XS . Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer . Journal of Surgical Oncology . 103 . 3 . 283–9 . March 2011 . 21337558 . 10.1002/jso.21802 . 30706374 .

Notes and References

1. Web site: Entrez Gene: Ubiquitin specific peptidase 22 .
2. Web site: Q9UPT9 (UBP22_HUMAN) . UniProt .