USP2 explained

Ubiquitin carboxyl-terminal hydrolase 2 is an enzyme that in humans is encoded by the USP2 gene.^{[1] [2]}

Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478).[supplied by OMIM]

Further reading

• D'Andrea A, Pellman D . Deubiquitinating enzymes: a new class of biological regulators . Crit. Rev. Biochem. Mol. Biol. . 33 . 5 . 337–52 . 1999 . 9827704 . 10.1080/10409239891204251 .
• Baek SH, Choi KS, Yoo YJ, etal . Molecular cloning of a novel ubiquitin-specific protease, UBP41, with isopeptidase activity in chick skeletal muscle . J. Biol. Chem. . 272 . 41 . 25560–5 . 1997 . 9325273 . 10.1074/jbc.272.41.25560 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gewies A, Grimm S . UBP41 is a proapoptotic ubiquitin-specific protease . Cancer Res. . 63 . 3 . 682–8 . 2003 . 12566314 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Bouwmeester T, Bauch A, Ruffner H, etal . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Graner E, Tang D, Rossi S, etal . The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer . Cancer Cell . 5 . 3 . 253–61 . 2004 . 15050917 . 10.1016/S1535-6108(04)00055-8 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Stevenson LF, Sparks A, Allende-Vega N, etal . The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2 . EMBO J. . 26 . 4 . 976–86 . 2007 . 17290220 . 10.1038/sj.emboj.7601567 . 1852834 .

Notes and References

1. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C . Human and mouse proteases: a comparative genomic approach . Nat Rev Genet . 4 . 7 . 544–58 . Jul 2003 . 12838346 . 10.1038/nrg1111 . 2856065 .
2. Web site: Entrez Gene: USP2 ubiquitin specific peptidase 2.