USP15 explained

Ubiquitin carboxyl-terminal hydrolase 15 is an enzyme that in humans is encoded by the USP15 gene.^{[1] [2]}

Ubiquitin is a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, which is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs).^[2]

See also

• USP1 (MIM 603478).

Further reading

• Nakajima D . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . vanc. Okazaki N . Yamakawa H . 3 . Kikuno . R . Ohara . O . Nagase . T . free .
• D'Andrea A, Pellman D . Deubiquitinating enzymes: a new class of biological regulators . Crit. Rev. Biochem. Mol. Biol. . 33 . 5 . 337–52 . 1999 . 9827704 . 10.1080/10409239891204251 .
• Ewing RM . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . vanc. Chu P . Elisma F . 3 . Li . Hongyan . Taylor . Paul . Climie . Shane . McBroom-Cerajewski . Linda . Robinson . Mark D . O'Connor . Liam .
• Beausoleil SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . vanc. Villén J . Gerber SA . 3 . Rush . John . Gygi . Steven P . 14294292 .
• de Jong RN . Solution structure of the human ubiquitin-specific protease 15 DUSP domain . J. Biol. Chem. . 281 . 8 . 5026–31 . 2006 . 16298993 . 10.1074/jbc.M510993200 . vanc. Ab E . Diercks T . 3 . Truffault . V . Daniëls . M . Kaptein . R . Folkers . GE . free .
• Hetfeld BK . The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1 . Curr. Biol. . 15 . 13 . 1217–21 . 2005 . 16005295 . 10.1016/j.cub.2005.05.059 . vanc. Helfrich A . Kapelari B . 3 . Scheel . Hartmut . Hofmann . Kay . Guterman . Adi . Glickman . Michael . Schade . Rüdiger . Kloetzel . Peter-Michael . 15396259 . free .
• Soboleva TA, Jans DA, Johnson-Saliba M, Baker RT . Nuclear-cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme . J. Biol. Chem. . 280 . 1 . 745–52 . 2005 . 15494318 . 10.1074/jbc.M401394200 . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Angelats C . Isolation and characterization of the mouse ubiquitin-specific protease Usp15 . Mamm. Genome . 14 . 1 . 31–46 . 2003 . 12532266 . 10.1007/s00335-002-3035-0 . vanc. Wang XW . Jermiin LS . 3 . Copeland . Neal G. . Jenkins . Nancy A. . Baker . Rohan T. . 23215004 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Baker RT . Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases . Genomics . 59 . 3 . 264–74 . 1999 . 10444327 . 10.1006/geno.1999.5879 . vanc. Wang XW . Woollatt E . 3 . White . Julia A. . Sutherland . Grant R. .
• Nagase T . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res. . 5 . 1 . 31–9 . 1998 . 9628581 . 10.1093/dnares/5.1.31 . vanc. Ishikawa K . Miyajima N . 3 . Tanaka . A . Kotani . H . Nomura . N . Ohara . O . free .

Notes and References

1. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C . Human and mouse proteases: a comparative genomic approach . Nat Rev Genet . 4 . 7 . 544–58 . Jul 2003 . 12838346 . 10.1038/nrg1111 . 2856065 .
2. Web site: Entrez Gene: USP15 ubiquitin specific peptidase 15.