USP10 explained

Ubiquitin specific peptidase 10, also known as USP10, is an enzyme which in humans is encoded by the USP10 gene.^[1]

Function

Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene.^[1]

Interactions

USP10 has been shown to interact with G3BP1.^[2] In the endothelium, USP10 regulates Notch signaling by slowing down the degradation of the intracellular domain of NOTCH1. ^[3]

Further reading

• D'Andrea A, Pellman D . Deubiquitinating enzymes: a new class of biological regulators. . Crit. Rev. Biochem. Mol. Biol. . 33 . 5 . 337–52 . 1999 . 9827704 . 10.1080/10409239891204251 .
• Puente XS, Sánchez LM, Overall CM, López-Otín C . Human and mouse proteases: a comparative genomic approach. . Nat. Rev. Genet. . 4 . 7 . 544–58 . 2003 . 12838346 . 10.1038/nrg1111 . 2856065 .
• Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N . Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. . DNA Res. . 3 . 1 . 17–24 . 1996 . 8724849 . 10.1093/dnares/3.1.17 . free .
• Soncini C, Berdo I, Draetta G . Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease. . Oncogene . 20 . 29 . 3869–79 . 2001 . 11439350 . 10.1038/sj.onc.1204553 . 7515868 . free .
• Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM . Lineage-specific gene duplication and loss in human and great ape evolution. . PLOS Biol. . 2 . 7 . E207 . 2006 . 15252450 . 449870 . 10.1371/journal.pbio.0020207 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Faus H, Meyer HA, Huber M, Bahr I, Haendler B . The ubiquitin-specific protease USP10 modulates androgen receptor function. . Mol. Cell. Endocrinol. . 245 . 1–2 . 138–46 . 2006 . 16368182 . 10.1016/j.mce.2005.11.011 . 24365493 .
• Grunda JM, Nabors LB, Palmer CA, Chhieng DC, Steg A, Mikkelsen T, Diasio RB, Zhang K, Allison D, Grizzle WE, Wang W, Gillespie GY, Johnson MR . Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM). . J. Neurooncol. . 80 . 3 . 261–74 . 2007 . 16773218 . 10.1007/s11060-006-9191-4 . 42007677 .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Deng S, Zhou H, Xiong R, Lu Y, Yan D, Xing T, Dong L, Tang E, Yang H . Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics. . Breast Cancer Res. Treat. . 104 . 1 . 21–30 . 2007 . 17004105 . 10.1007/s10549-006-9393-7 . 29643544 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Web site: Entrez Gene: USP10 ubiquitin specific peptidase 10.
2. Soncini C, Berdo I, Draetta G . Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease . Oncogene . 20 . 29 . 3869–79 . June 2001 . 11439350 . 10.1038/sj.onc.1204553 . 7515868 . free .
3. Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JW, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M . Deubiquitinase USP10 regulates Notch signaling in the endothelium. . Science . 364 . 6436 . 188–193 . April 2019 . 30975888 . 10.1126/science.aat0778 . 2019Sci...364..188L . 20.500.12105/9685 . 109940358 . free .