USE1 explained

Uncharacterized hematopoietic stem/progenitor cells protein MDS032, also known as MDS032, is a protein which in humans is encoded by the MDS032 gene.^{[1] [2]}

Function

D12, the mouse homolog of MDS032, is a SNARE protein involved with the Golgi secretory apparatus and with endosome-lysosome transport.^[2]

Further reading

• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Matsuda A, Suzuki Y, Honda G, etal . Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. . Oncogene . 22 . 21 . 3307–18 . 2003 . 12761501 . 10.1038/sj.onc.1206406 . 38880905 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Hirose H, Arasaki K, Dohmae N, etal . Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. . EMBO J. . 23 . 6 . 1267–78 . 2005 . 15029241 . 10.1038/sj.emboj.7600135 . 381410 .
• Nakajima K, Hirose H, Taniguchi M, etal . Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. . EMBO J. . 23 . 16 . 3216–26 . 2005 . 15272311 . 10.1038/sj.emboj.7600333 . 514507 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to biology: a functional genomics pipeline. . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Okumura AJ, Hatsuzawa K, Tamura T, etal . Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system. . J. Biol. Chem. . 281 . 7 . 4495–506 . 2006 . 16354670 . 10.1074/jbc.M509715200 . free .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006. . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .

Notes and References

1. Web site: Entrez Gene: MDS032 uncharacterized hematopoietic stem/progenitor cells protein MDS032.
2. Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I . Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system . J. Biol. Chem. . 281 . 7 . 4495–506 . February 2006 . 16354670 . 10.1074/jbc.M509715200 . free .