UQCRH explained

Cytochrome b-c1 complex subunit 6, mitochondrial is a protein that in humans is encoded by the UQCRH gene.^{[1] [2]}

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex; E.C. 1.10.2.2), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and "Rieske-associated protein".

Further reading

• Liu AY, Bradner RC . Elevated expression of the human mitochondrial hinge protein gene in cancer. . Cancer Res. . 53 . 11 . 2460–5 . 1993 . 7684318 .
• Kato S, Sekine S, Oh SW, etal . Construction of a human full-length cDNA bank. . Gene . 150 . 2 . 243–50 . 1995 . 7821789 . 10.1016/0378-1119(94)90433-2 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Modena P, Testi MA, Facchinetti F, etal . UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines . Oncogene . 22 . 29 . 4586–93 . 2003 . 12881716 . 10.1038/sj.onc.1206472 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wen JJ, Garg N . Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection . Free Radic. Biol. Med. . 37 . 12 . 2072–81 . 2005 . 15544925 . 10.1016/j.freeradbiomed.2004.09.011 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Ohta S, Goto K, Arai H, Kagawa Y . An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein . FEBS Lett . 226 . 1 . 171–5 . Jan 1988 . 2826252 . 10.1016/0014-5793(87)80573-2 . free .
2. Web site: Entrez Gene: UQCRH ubiquinol-cytochrome c reductase hinge protein. 2017-09-17. 2024-04-28. https://web.archive.org/web/20240428045823/https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7388. live.