UQCRC1 explained

Cytochrome b-c1 complex subunit 1, mitochondrial is a protein that in humans is encoded by the UQCRC1 gene.^{[1] [2]}

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and Rieske-associated protein.

Further reading

• Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T . Existence of common homologous elements in the transcriptional regulatory regions of human nuclear genes and mitochondrial gene for the oxidative phosphorylation system. . J. Biol. Chem. . 266 . 4 . 2333–8 . 1991 . 10.1016/S0021-9258(18)52248-1 . 1846623 . free .
• Broger C, Nałecz MJ, Azzi A . Interaction of cytochrome c with cytochrome bc1 complex of the mitochondrial respiratory chain. . Biochim. Biophys. Acta . 592 . 3 . 519–27 . 1980 . 6251869 . 10.1016/0005-2728(80)90096-1 .
• Islam MM . A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase . Biochem. Mol. Biol. Int. . 33 . 2 . 410 . 1994 . 7951059 . vanc. Tanaka M . Suzuki H . 3 . Torii . K . Hattori . N . Ozawa . T .
• Islam MM . A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase . Biochem. Mol. Biol. Int. . 33 . 4 . 815 . 1995 . 7981668 . vanc. Tanaka M . Suzuki H . 3 . Torii . K . Hattori . N . Ozawa . T .
• Islam MM . A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase . Biochem. Mol. Biol. Int. . 32 . 5 . 797–805 . 1994 . 8069229 . vanc. Tanaka M . Suzuki H . 3 . Torii . K . Hattori . N . Ozawa . T .
• Hughes GJ . Human liver protein map: update 1993 . Electrophoresis . 14 . 11 . 1216–22 . 1994 . 8313870 . 10.1002/elps.11501401181 . vanc. Frutiger S . Paquet N . 3 . Pasquali . Christian . Sanchez . Jean-Charles . Tissot . Jean-Daniel . Bairoch . Amos . Appel . Ron D. . Hochstrasser . Denis F. . 33424554 .
• Hillier LD . Generation and analysis of 280,000 human expressed sequence tags . Genome Res. . 6 . 9 . 807–28 . 1997 . 8889549 . 10.1101/gr.6.9.807 . vanc. Lennon G . Becker M . 3 . Bonaldo . M F . Chiapelli . B . Chissoe . S . Dietrich . N . Dubuque . T . Favello . A . free .
• Valnot I . A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency . Hum. Genet. . 104 . 6 . 460–6 . 1999 . 10453733 . 10.1007/s004390050988 . vanc. Kassis J . Chretien D . 3 . De Lonlay . Pascale . Parfait . Béatrice . Munnich . Arnold . Kachaner . Jean . Rustin . Pierre . Rötig . Agnès . 30584267 .
• Hu WH . Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP) . J. Neurochem. . 81 . 1 . 36–45 . 2002 . 12067236 . 10.1046/j.1471-4159.2002.00788.x . vanc. Hausmann ON . Yan MS . 3 . Walters . Winston M. . Wong . Paul K. Y. . Bethea . John R. . 38794348 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Aboulaich N, Vainonen JP, Strålfors P, Vener AV . Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes . Biochem. J. . 383 . Pt 2 . 237–48 . 2005 . 15242332 . 10.1042/BJ20040647 . 1134064 .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Wen JJ, Garg N . Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection . Free Radic. Biol. Med. . 37 . 12 . 2072–81 . 2005 . 15544925 . 10.1016/j.freeradbiomed.2004.09.011 .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Kulawiec M . Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer . Cancer Biol. Ther. . 5 . 8 . 967–75 . 2007 . 16775426 . 10.4161/cbt.5.8.2880. vanc. Arnouk H . Desouki MM . 3 . Kazim . L . Still . I . Singh . KK . 84608368 .
• Ewing RM . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . vanc. Chu P . Elisma F . 3 . Li . Hongyan . Taylor . Paul . Climie . Shane . McBroom-Cerajewski . Linda . Robinson . Mark D . O'Connor . Liam .

Notes and References

1. Hoffman GG, Lee S, Christiano AM, Chung-Honet LC, Cheng W, Katchman S, Uitto J, Greenspan DS . Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase . J Biol Chem . 268 . 28 . 21113–9 . Nov 1993 . 10.1016/S0021-9258(19)36900-5 . 8407948 . free .
2. Web site: Entrez Gene: UQCRC1 ubiquinol-cytochrome c reductase core protein I.