UQCR10 explained

Ubiquinol-cytochrome c reductase complex (7.2 kD), also known as UCRC or UQCR10, is a human gene.^[1]

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, UQCRQ https://www.ncbi.nlm.nih.gov/nuccore/98986462("11kDa protein"), UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, UCRC("cyt. c1 associated protein"), and UQCR https://www.ncbi.nlm.nih.gov/nucleotide/19923785("Rieske-associated protein").

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Book: Schägger H, Brandt U, Gencic S, von Jagow G . Mitochondrial Biogenesis and Genetics Part A . Ubiquinol-cytochrome-c reductase from human and bovine mitochondria . 260 . 82–96 . 8592474 . 10.1016/0076-6879(95)60132-5 . Methods in Enzymology . 1995 . 978-0-12-182161-6 . registration . https://archive.org/details/mitochondrialbio260atta/page/82 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Iwata S, Lee JW, Okada K, etal . Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex . Science . 281 . 5373 . 64–71 . 1998 . 9651245 . 10.1126/science.281.5373.64 . 1998Sci...281...64I .
• Dunham I, Shimizu N, Roe BA, etal . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Zhang QH, Ye M, Wu XY, etal . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 .
• Wistow G, Bernstein SL, Wyatt MK, etal . Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants . Mol. Vis. . 8 . 171–84 . 2002 . 12107413 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Guzy RD, Hoyos B, Robin E, etal . Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing . Cell Metab. . 1 . 6 . 401–8 . 2005 . 16054089 . 10.1016/j.cmet.2005.05.001 . free .

Notes and References

1. Web site: Entrez Gene: UCRC ubiquinol-cytochrome c reductase complex (7.2 kD).