UPP1 explained

Uridine phosphorylase 1 is an enzyme that in humans is encoded by the UPP1 gene.^{[1] [2] [3]} It belongs to the uridine phosphorylase enzyme family.

Interactions

UPP1 has been shown to interact with Vimentin.^[4]

Further reading

• Pizzorno G, Cao D, Leffert JJ, etal . Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update . Biochim. Biophys. Acta . 1587 . 2–3 . 133–44 . 2002 . 12084455 . 10.1016/s0925-4439(02)00076-5.
• Watanabe S, Uchida T . Cloning and expression of human uridine phosphorylase . Biochem. Biophys. Res. Commun. . 216 . 1 . 265–72 . 1995 . 7488099 . 10.1006/bbrc.1995.2619 .
• Russell RL, Cao D, Zhang D, etal . Uridine phosphorylase association with vimentin. Intracellular distribution and localization . J. Biol. Chem. . 276 . 16 . 13302–7 . 2001 . 11278417 . 10.1074/jbc.M008512200 . free .
• Miyashita H, Takebayashi Y, Eliason JF, etal . Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma . Cancer . 94 . 11 . 2959–66 . 2002 . 12115385 . 10.1002/cncr.10568 . 9484010 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Temmink OH, de Bruin M, Laan AC, etal . The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells . Int. J. Biochem. Cell Biol. . 38 . 10 . 1759–65 . 2006 . 16798057 . 10.1016/j.biocel.2006.04.007 .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Uridine phosphorylase 1 (UPP1)

Notes and References

1. Denney RM, Nichols EA, Ruddle FH . Assignment of a gene for uridine phosphorylase to chromosome 7 . Cytogenet Cell Genet . 22 . 1–6 . 195–9 . September 1979 . 752472 . 10.1159/000130934 .
2. Kanzaki A, Takebayashi Y, Bando H, Eliason JF, Watanabe Si S, Miyashita H, Fukumoto M, Toi M, Uchida T . Expression of uridine and thymidine phosphorylase genes in human breast carcinoma . Int J Cancer . 97 . 5 . 631–5 . January 2002 . 11807789 . 10.1002/ijc.10105 . 40565516 . free .
3. Web site: Entrez Gene: UPP1 uridine phosphorylase 1.
4. Russell . R L . Cao D . Zhang D . Handschumacher R E . Pizzorno G . April 2001 . Uridine phosphorylase association with vimentin. Intracellular distribution and localization . J. Biol. Chem. . 276 . 16 . 13302–7 . United States. 0021-9258. 11278417 . 10.1074/jbc.M008512200 . free .