Uroplakin-2 Explained

Uroplakin-2 (UP2) is a protein that in humans is encoded by the UPK2 gene.^{[1] [2] [3]}

Further reading

• Lin JH, Wu XR, Kreibich G, Sun TT . Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membrane . J. Biol. Chem. . 269 . 3 . 1775–84 . 1994 . 10.1016/S0021-9258(17)42095-3 . 7507484 . free .
• Wu XR, Lin JH, Walz T, etal . Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins . J. Biol. Chem. . 269 . 18 . 13716–24 . 1994 . 10.1016/S0021-9258(17)36889-8 . 8175808 . free .
• Yuasa T, Yoshiki T, Isono T, etal . Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients . Int. J. Urol. . 6 . 6 . 286–92 . 1999 . 10404304 . 10.1046/j.1442-2042.1999.00064.x . 43597402 .
• Li SM, Zhang ZT, Chan S, etal . Detection of circulating uroplakin-positive cells in patients with transitional cell carcinoma of the bladder . J. Urol. . 162 . 3 Pt 1 . 931–5 . 1999 . 10458411 . 10.1097/00005392-199909010-00093 .
• Ogawa K, Johansson SL, Cohen SM . Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract . Am. J. Pathol. . 155 . 4 . 1047–50 . 1999 . 10514386 . 10.1016/S0002-9440(10)65206-6. 1867018 .
• Tu L, Sun TT, Kreibich G . Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum . Mol. Biol. Cell . 13 . 12 . 4221–30 . 2003 . 12475947 . 10.1091/mbc.E02-04-0211 . 138628 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Hirata H, Hisatomi H, Kawakita M, etal . Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction . Oncol. Rep. . 10 . 4 . 963–6 . 2004 . 12792753 . 10.3892/or.10.4.963.
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Chen F, Zeng F, Tong Q, etal . Cloning of human uroplakin II gene from Chinese transitional cell carcinoma of bladder and construction of its eukaryotic expression vector . J. Huazhong Univ. Sci. Technol. Med. Sci. . 25 . 2 . 188–90, 211 . 2006 . 16116969 . 10.1007/BF02873573 . 7772680 .
• Jenkins D, Bitner-Glindzicz M, Malcolm S, etal . Mutation analyses of Uroplakin II in children with renal tract malformations . Nephrol. Dial. Transplant. . 21 . 12 . 3415–21 . 2007 . 17012268 . 10.1093/ndt/gfl465 . free .

Notes and References

1. Wu RL, Osman I, Wu XR, Lu ML, Zhang ZF, Liang FX, Hamza R, Scher H, Cordon-Cardo C, Sun TT . Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation . Cancer Res . 58 . 6 . 1291–7 . 9515818. 1998 .
2. Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J . Uroplakin gene expression by normal and neoplastic human urothelium . Am J Pathol . 153 . 6 . 1957–67 . Dec 1998 . 9846985 . 1866332 . 10.1016/S0002-9440(10)65709-4 .
3. Web site: Entrez Gene: UPK2 uroplakin 2.