UNC93A explained

Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene.^[1]

Unc93A is a major facilitator superfamily (MFS), and a putative solute carrier in humans.^{[2] [3]} It belongs to the atypical SLCs that was recently listed. It is therefore presumed that UNC93A is a transporter protein.

UNC93A is closely related to UNC93B1 and MFSD11.^{[4] [5]}

UNC93A is affected by amino acid deprivation in cell cortex cultures and starvation in in vivo samples.

It is expressed in neurons, with staining close to the plasma membrane.

Read also ^{[6] [7]} for functional studies in C.elegans.

For you who are interested to read more about Unc93A in different species, see: ^[8]

Further reading

• Liu Y, Dodds P, Emilion G, Mungall AJ, Dunham I, Beck S, Wells RS, Charnock FM, Ganesan TS . The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer . BMC Genetics . 3 . 20 . October 2002 . 12381271 . 134458 . 10.1186/1471-2156-3-20 . free .

Notes and References

1. Web site: Entrez Gene: Unc-93 homolog A (C. elegans) .
2. Perland E, Fredriksson R . Classification Systems of Secondary Active Transporters . Trends in Pharmacological Sciences . 38 . 3 . 305–315 . March 2017 . 27939446 . 10.1016/j.tips.2016.11.008 .
3. Perland E, Bagchi S, Klaesson A, Fredriksson R . Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression . Open Biology . 7 . 9 . September 2017 . 28878041 . 5627054 . 10.1098/rsob.170142 . 170142.
4. Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R . The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice . English . Frontiers in Molecular Neuroscience . 10 . 351 . 2017 . 29163028 . 10.3389/fnmol.2017.00351 . 5671512. free .
5. Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R . The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis . PLOS ONE . 11 . 6 . e0156912 . 2016 . 27272503 . 4896477 . 10.1371/journal.pone.0156912 . 2016PLoSO..1156912P . free .
6. Levin JZ, Horvitz HR . The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction . The Journal of Cell Biology . 117 . 1 . 143–55 . April 1992 . 1313436 . 2289394 . 10.1083/jcb.117.1.143.
7. de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR . sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans . The Journal of Neuroscience . 23 . 27 . 9133–45 . October 2003 . 14534247 . 10.1523/JNEUROSCI.23-27-09133.2003 . 6740817 .
8. Ceder. Mikaela M.. Aggarwal. Tanya. Hosseini. Kimia. Maturi. Varun. Patil. Sourabh. Perland. Emelie. Williams. Michael J.. Fredriksson. Robert. 2020. CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A. Frontiers in Cell and Developmental Biology. English. 8. 580291. 10.3389/fcell.2020.580291. 33163493. 7591606. 2296-634X. free.