UNC84A explained

Protein unc-84 homolog A is a protein that in humans is encoded by the UNC84A gene.^{[1] [2]}

This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Nagase T, Ishikawa K, Suyama M, etal . Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 5 . 5 . 277–86 . 1999 . 9872452 . 10.1093/dnares/5.5.277 . free .
• Malone CJ, Fixsen WD, Horvitz HR, Han M . UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development . Development . 126 . 14 . 3171–81 . 1999 . 10.1242/dev.126.14.3171 . 10375507 .
• Bray JD, Chennathukuzhi VM, Hecht NB . Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X . Genomics . 79 . 6 . 799–808 . 2002 . 12036294 . 10.1006/geno.2002.6779 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Schirmer EC, Florens L, Guan T, etal . Nuclear membrane proteins with potential disease links found by subtractive proteomics . Science . 301 . 5638 . 1380–2 . 2003 . 12958361 . 10.1126/science.1088176 . 2003Sci...301.1380S . 23832536 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Padmakumar VC, Libotte T, Lu W, etal . The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope . J. Cell Sci. . 118 . Pt 15 . 3419–30 . 2005 . 16079285 . 10.1242/jcs.02471 . free .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Hasan S, Güttinger S, Mühlhäusser P, etal . Nuclear envelope localization of human UNC84A does not require nuclear lamins . FEBS Lett. . 580 . 5 . 1263–8 . 2006 . 16445915 . 10.1016/j.febslet.2006.01.039 . 29434638 . free . 2006FEBSL.580.1263H .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Wang Q, Du X, Cai Z, Greene MI . Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome . DNA Cell Biol. . 25 . 10 . 554–62 . 2006 . 17132086 . 10.1089/dna.2006.25.554 .
• Chi YH, Haller K, Peloponese JM, Jeang KT . Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes . J. Biol. Chem. . 282 . 37 . 27447–58 . 2007 . 17631499 . 10.1074/jbc.M703098200 . 44621298 . free .

Notes and References

1. Dreger M, Bengtsson L, Schoneberg T, Otto H, Hucho F . Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane . Proc Natl Acad Sci U S A . 98 . 21 . 11943–8 . Oct 2001 . 11593002 . 59747 . 10.1073/pnas.211201898 . 2001PNAS...9811943D . free .
2. Web site: Entrez Gene: UNC84A unc-84 homolog A (C. elegans).