UNC5A explained

Netrin receptor UNC5A is a protein that in humans is encoded by the UNC5A gene.^[1]

UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM]

Interactions

UNC5A has been shown to interact with MAGED1.^[2]

Further reading

• Arakawa H . Netrin-1 and its receptors in tumorigenesis . Nature Reviews. Cancer . 4 . 12 . 978–87 . December 2004 . 15573119 . 10.1038/nrc1504 . 867903 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Nagase T, Kikuno R, Ohara O . Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins . DNA Research . 8 . 6 . 319–27 . December 2001 . 11853319 . 10.1093/dnares/8.6.319 .
• Williams ME, Strickland P, Watanabe K, Hinck L . UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE . The Journal of Biological Chemistry . 278 . 19 . 17483–90 . May 2003 . 12598531 . 10.1074/jbc.M300415200 . free .
• Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H . p53RDL1 regulates p53-dependent apoptosis . Nature Cell Biology . 5 . 3 . 216–23 . March 2003 . 12598906 . 10.1038/ncb943 . 7017409 .
• Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, Saurin JC, Romeo G, Mehlen P . 6 . The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment . Proceedings of the National Academy of Sciences of the United States of America . 100 . 7 . 4173–8 . April 2003 . 12655055 . 153067 . 10.1073/pnas.0738063100 . 2003PNAS..100.4173T . free .
• Geisbrecht BV, Dowd KA, Barfield RW, Longo PA, Leahy DJ . Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin . The Journal of Biological Chemistry . 278 . 35 . 32561–8 . August 2003 . 12810718 . 10.1074/jbc.M302943200 . free .
• Llambi F, Lourenço FC, Gozuacik D, Guix C, Pays L, Del Rio G, Kimchi A, Mehlen P . 6 . The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase . The EMBO Journal . 24 . 6 . 1192–201 . March 2005 . 15729359 . 556396 . 10.1038/sj.emboj.7600584 .

Notes and References

1. Web site: Entrez Gene: UNC5A unc-5 homolog A (C. elegans).
2. Williams ME, Strickland P, Watanabe K, Hinck L . UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE . The Journal of Biological Chemistry . 278 . 19 . 17483–90 . May 2003 . 12598531 . 10.1074/jbc.M300415200 . free .