ULK2 explained

unc-51-like kinase 2 (C. elegans)
Hgncid:	13480
Symbol:	ULK2
Entrezgene:	9706
Omim:	608650
Refseq:	NM_014683
Uniprot:	Q8IYT8
Ecnumber:	2.7.11.1
Chromosome:	17
Arm:	p
Band:	11.2

Unc-51-like kinase 2 (C. elegans) also known as ULK2 is an enzyme which in humans is encoded by the ULK2 gene.^[1] The gene is located within the Smith–Magenis syndrome region on chromosome 17.

Structure and function

This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain.^[2] ULK2 and the GTPase activating protein SynGAP function cooperatively in axon formation.^[3]

Notes and References

1. Yan J, Kuroyanagi H, Tomemori T, Okazaki N, Asato K, Matsuda Y, Suzuki Y, Ohshima Y, Mitani S, Masuho Y, Shirasawa T, Muramatsu M . Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains . Oncogene . 18 . 43 . 5850–9 . October 1999 . 10557072 . 10.1038/sj.onc.1202988 . free .
2. Web site: Entrez Gene: ULK2 .
3. Tomoda T, Kim JH, Zhan C, Hatten ME . Role of Unc51.1 and its binding partners in CNS axon outgrowth . Genes Dev. . 18 . 5 . 541–58 . March 2004 . 15014045 . 374236 . 10.1101/gad.1151204 .