UHRF2 explained

E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene.^{[1] [2]}

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.^[3]

Further reading

• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Unoki M, Nishidate T, Nakamura Y . ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. . Oncogene . 23 . 46 . 7601–10 . 2004 . 15361834 . 10.1038/sj.onc.1208053 . 21948278 .
• Colland F, Jacq X, Trouplin V, etal . Functional proteomics mapping of a human signaling pathway. . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 .
• Li Y, Mori T, Hata H, etal . NIRF induces G1 arrest and associates with Cdk2. . Biochem. Biophys. Res. Commun. . 319 . 2 . 464–8 . 2004 . 15178429 . 10.1016/j.bbrc.2004.04.190 .
• Humphray SJ, Oliver K, Hunt AR, etal . DNA sequence and analysis of human chromosome 9. . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . 2004Natur.429..369H .
• Mori T, Li Y, Hata H, Kochi H . NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein. . FEBS Lett. . 557 . 1–3 . 209–14 . 2004 . 14741369 . 10.1016/S0014-5793(03)01495-9 . 10006213 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .

Notes and References

1. Mori T, Li Y, Hata H, Ono K, Kochi H . NIRF, a novel RING finger protein, is involved in cell-cycle regulation . Biochem Biophys Res Commun . 296 . 3 . 530–6 . Aug 2002 . 12176013 . 10.1016/S0006-291X(02)00890-2 .
2. Web site: Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2.
3. Web site: Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2.