UH-301 explained

(S)-UH-301 is a drug and research chemical widely used in scientific studies. It acts as a selective 5-HT1A receptor silent antagonist.[1] It is structurally related to 8-OH-DPAT. UH-301 was found to produce a head-twitch response in mice which is usually typical of 5-HT2A agonist drugs, and has subsequently been used to investigate how 5-HT1A receptor activity modulates 5-HT2A receptors downstream.[2]

See also

Notes and References

  1. Björk L, Cornfield LJ, Nelson DL, Hillver SE, Andén NE, Lewander T, Hacksell U . Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects . The Journal of Pharmacology and Experimental Therapeutics . 258 . 1 . 58–65 . July 1991 . 1830099 .
  2. Darmani NA, Reeves SL . The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice . Pharmacology, Biochemistry, and Behavior . 55 . 1 . 1–10 . September 1996 . 8870031 . 10.1016/0091-3057(96)00072-X . 25607128 .

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