UGT2B15 explained

UDP-glucuronosyltransferase 2B15 is an enzyme that in humans is encoded by the UGT2B15 gene.^{[1] [2]}

The UGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B8 demonstrates reactivity with estriol. See UGT2B4 (MIM 600067).[supplied by OMIM]

Further reading

• Coffman BL, Tephly TR, Irshaid YM, etal . Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase. . Arch. Biochem. Biophys. . 281 . 1 . 170–5 . 1990 . 2116769 . 10.1016/0003-9861(90)90428-2 .
• Irshaid YM, Tephly TR . Isolation and purification of two human liver UDP-glucuronosyltransferases. . Mol. Pharmacol. . 31 . 1 . 27–34 . 1987 . 3100939 .
• Green MD, Clarke DJ, Oturu EM, etal . Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols. . Arch. Biochem. Biophys. . 322 . 2 . 460–8 . 1995 . 7574722 . 10.1006/abbi.1995.1489 .
• Green MD, Oturu EM, Tephly TR . Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. . Drug Metab. Dispos. . 22 . 5 . 799–805 . 1995 . 7835232 .
• Chen F, Ritter JK, Wang MG, etal . Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms. . Biochemistry . 32 . 40 . 10648–57 . 1993 . 8399210 . 10.1021/bi00091a015 .
• Guillemette C, Lévesque E, Beaulieu M, etal . Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells. . Endocrinology . 138 . 7 . 2998–3005 . 1997 . 9202245 . 10.1210/endo.138.7.5226 . free .
• Lévesque E, Beaulieu M, Green MD, etal . Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene. . Pharmacogenetics . 7 . 4 . 317–25 . 1997 . 9295060 . 10.1097/00008571-199708000-00007 .
• Strassburg CP, Strassburg A, Nguyen N, etal . Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. . Biochem. J. . 338 . 2. 489–98 . 1999 . 10024527 . 10.1042/0264-6021:3380489 . 1220077 .
• Tchernof A, Lévesque E, Beaulieu M, etal . Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method. . Clin. Endocrinol. . 50 . 5 . 637–42 . 1999 . 10468930 . 10.1046/j.1365-2265.1999.00709.x . 43030627 .
• Strassburg CP, Kneip S, Topp J, etal . Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. . J. Biol. Chem. . 275 . 46 . 36164–71 . 2000 . 10748067 . 10.1074/jbc.M002180200 . free .
• Gsur A, Preyer M, Haidinger G, etal . A polymorphism in the UDP-Glucuronosyltransferase 2B15 gene (D85Y) is not associated with prostate cancer risk. . Cancer Epidemiol. Biomarkers Prev. . 11 . 5 . 497–8 . 2002 . 12010866 .
• Iida A, Saito S, Sekine A, etal . Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8. . J. Hum. Genet. . 47 . 10 . 505–10 . 2002 . 12376738 . 10.1007/s100380200075 . free .
• Court MH, Duan SX, Guillemette C, etal . Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9. . Drug Metab. Dispos. . 30 . 11 . 1257–65 . 2003 . 12386133 . 10.1124/dmd.30.11.1257 .
• Kanaya J, Takashima M, Koh E, Namiki M . Androgen-independent growth in LNCaP cell lines and steroid uridine diphosphate-glucuronosyltransferase expression. . Asian J. Androl. . 5 . 1 . 9–13 . 2003 . 12646996 .
• Zhang JY, Zhan J, Cook CS, etal . Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism. . Drug Metab. Dispos. . 31 . 5 . 652–8 . 2003 . 12695355 . 10.1124/dmd.31.5.652 . 23434477 .
• Tomboc M, Witchel SF . Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism. . J. Pediatr. Endocrinol. Metab. . 16 . 5 . 719–26 . 2003 . 12880121 . 10.1515/jpem.2003.16.5.719. 32217321 .
• Court MH, Hao Q, Krishnaswamy S, etal . UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver. . J. Pharmacol. Exp. Ther. . 310 . 2 . 656–65 . 2005 . 15044558 . 10.1124/jpet.104.067660 . 5946464 .
• Toide K, Umeda S, Yamazaki H, etal . A major genotype in UDP-glucuronosyltransferase 2B15. . Drug Metab. Pharmacokinet. . 17 . 2 . 164–6 . 2005 . 15618667 . 10.2133/dmpk.17.164 .
• Chouinard S, Pelletier G, Bélanger A, Barbier O . 10971899 . Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium. . Endocr. Res. . 30 . 4 . 717–25 . 2005 . 15666817 . 10.1081/ERC-200044014 .

Notes and References

1. Monaghan G, Clarke DJ, Povey S, See CG, Boxer M, Burchell B . Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13 . Genomics . 23 . 2 . 496–9 . Feb 1995 . 7835904 . 10.1006/geno.1994.1531 .
2. Web site: Entrez Gene: UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15.