UGT2B10 explained

UDP-glucuronosyltransferase 2B10 is an enzyme that in humans is encoded by the UGT2B10 gene.^{[1] [2]} It is responsible for glucuronidation of nicotine and cotinine.^{[3] [4]}

See also

• UGT2B17

Further reading

• Chen G, Dellinger RW, Gallagher CJ, Sun D, Lazarus P . Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines . Pharmacogenetics and Genomics . 18 . 3 . 181–91 . March 2008 . 18300939 . 10.1097/FPC.0b013e3282f4dbdd . 19295110 .
• Chen G, Blevins-Primeau AS, Dellinger RW, Muscat JE, Lazarus P . Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism . Cancer Research . 67 . 19 . 9024–9 . October 2007 . 17909004 . 10.1158/0008-5472.CAN-07-2245 .
• Kaivosaari S, Toivonen P, Hesse LM, Koskinen M, Court MH, Finel M . Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10 . Molecular Pharmacology . 72 . 3 . 761–8 . September 2007 . 17576790 . 10.1124/mol.107.037093 . 6062166 .
• Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD . Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry . Journal of Proteome Research . 4 . 6 . 2070–80 . 2006 . 16335952 . 1850943 . 10.1021/pr0502065 .
• Strassburg CP, Kneip S, Topp J, Obermayer-Straub P, Barut A, Tukey RH, Manns MP . Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine . The Journal of Biological Chemistry . 275 . 46 . 36164–71 . November 2000 . 10748067 . 10.1074/jbc.M002180200 . free .
• Strassburg CP, Strassburg A, Nguyen N, Li Q, Manns MP, Tukey RH . Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus . The Biochemical Journal . 338 (Pt 2) . 2 . 489–98 . March 1999 . 10024527 . 1220077 . 10.1042/0264-6021:3380489 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI . cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily . Biochemical and Biophysical Research Communications . 194 . 1 . 496–503 . July 1993 . 8333863 . 10.1006/bbrc.1993.1847 .
2. Web site: Entrez Gene: UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10.
3. Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P . Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms . Cancer Research . 70 . 19 . 7543–52 . October 2010 . 20876810 . 2998997 . 10.1158/0008-5472.CAN-09-4582 .
4. Wassenaar CA, Conti DV, Das S, Chen P, Cook EH, Ratain MJ, Benowitz NL, Tyndale RF . 6 . UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers . Cancer Epidemiology, Biomarkers & Prevention . 24 . 1 . 94–104 . January 2015 . 25277794 . 4294984 . 10.1158/1055-9965.EPI-14-0804 .