UDP-sulfoquinovose synthase explained
UDPsulfoquinovose synthase |
Ec Number: | 3.13.1.1 |
Go Code: | 0046507 |
UDP-sulfoquinovose synthase is an enzyme that catalyzes the chemical reaction
UDP-glucose + sulfite
UDP-6-sulfoquinovose + H
2O
Thus, the two substrates of this enzyme are UDP-glucose and sulfite, whereas its two products are UDP-6-sulfoquinovose and H2O.[1]
In a subsequent reaction catalyzed by sulfoquinovosyl diacylglycerol synthase, the sulfoquinovose portion of UDP-sulfoquinovose is combined with diacyglycerol to produce the sulfolipid sulfoquinovosyl diacylglycerol (SQDG).[2]
This enzyme belongs to the family of hydrolases, specifically those acting on carbon-sulfur bonds. The systematic name of this enzyme class is UDP-6-sulfo-6-deoxyglucose sulfohydrolase. Other names in common use include sulfite:UDP-glucose sulfotransferase, and UDP-sulfoquinovose synthase. This enzyme participates in nucleotide sugars metabolism and glycerolipid metabolism.
The 3-dimensional structure of the enzyme is known from Protein Data Bank entries 1qrr (Mulichak et al., 1999), 1i24, 1i2b and 1i2c.
See also
References
- Essigmann B, Guler S, Narang RA, Linke D, Benning C . 1998 . Phosphate availability affects the thylakoid lipid composition and the expression of SQD1, a gene required for sulfolipid biosynthesis in Arabidopsis thaliana . Proc. Natl. Acad. Sci. U.S.A. . 95 . 1950 - 5 . 9465123 . 10.1073/pnas.95.4.1950 . 4 . 19220 . 1998PNAS...95.1950E . free .
- Essigmann B, Hespenheide BM, Kuhn LA, Benning C . 1999 . Prediction of the active-site structure and NAD(+) binding in SQD1, a protein essential for sulfolipid biosynthesis in Arabidopsis . Arch. Biochem. Biophys. . 369 . 30 - 41 . 10462438 . 10.1006/abbi.1999.1344 . 1 .
- Sanda S, Leustek T, Theisen MJ, Garavito RM, Benning C . 2001 . Recombinant Arabidopsis SQD1 converts UDP-glucose and sulfite to the sulfolipid head group precursor UDP-sulfoquinovose in vitro . J. Biol. Chem. . 276 . 3941 - 6 . 11073956 . 10.1074/jbc.M008200200 . 6 . free .
Notes and References
- Mulichak. AM. Theisen. MJ. Essigmann. B. Benning. C. Garavito. RM. Crystal structure of SQD1, an enzyme involved in the biosynthesis of the plant sulfolipid headgroup donor UDP-sulfoquinovose.. Proceedings of the National Academy of Sciences of the United States of America. 9 November 1999. 96. 23. 13097–102. 10557279. 23906. 10.1073/pnas.96.23.13097. 1999PNAS...9613097M. free.
- Goddard-Borger. ED. Williams. SJ. Sulfoquinovose in the biosphere: occurrence, metabolism and functions.. The Biochemical Journal. 20 February 2017. 474. 5. 827–849. 10.1042/BCJ20160508. 28219973.