UDP-sugar diphosphatase explained

UDP-sugar diphosphatase
Ec Number:	3.6.1.45
Cas Number:	57127-20-5
Go Code:	0008768

In enzymology, an UDP-sugar diphosphatase is an enzyme that catalyzes the chemical reaction

UDP-sugar + H₂O

\rightleftharpoons UMP + alpha-D-aldose 1-phosphate

Thus, the two substrates of this enzyme are UDP-sugar and H₂O, whereas its two products are UMP and alpha-D-aldose 1-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is UDP-sugar sugarphosphohydrolase. Other names in common use include nucleosidediphosphate-sugar pyrophosphatase, nucleosidediphosphate-sugar diphosphatase, UDP-sugar hydrolase, and UDP-sugar pyrophosphatase.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes,,,,, and .

References

• Garrett AR, Johnson LA, Beacham IR . 1989 . Isolation, molecular characterization and expression of the ushB gene of Salmonella typhimurium which encodes a membrane-bound UDP-sugar hydrolase . Mol. Microbiol. . 3 . 177 - 86 . 2548058 . 10.1111/j.1365-2958.1989.tb01806.x . 2 . 23200294 .
• Glaser L, Melo A, Paul R . 1987 . Uridine diphosphate sugar hydrolase. Purification of enzyme and protein inhibitor . J. Biol. Chem. . 242 . 1944 - 1954 . 5337593 . 8.