UDP-glucuronic acid dehydrogenase explained

UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)
Ec Number:	1.1.1.305

UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) (UDP-GlcUA decarboxylase, ArnADH) is an enzyme with systematic name UDP-glucuronate:NAD⁺ oxidoreductase (decarboxylating).^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

UDP-glucuronate + NAD⁺

\rightleftharpoons UDP-beta-L-threo-pentapyranos-4-ulose + CO₂ + NADH + H⁺

The activity is part of a bifunctional enzyme also performing the reaction of EC 2.1.2.13 (UDP-4-amino-4-deoxy-L-arabinose formyltransferase).

Notes and References

1. Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR . A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose . The Journal of Biological Chemistry . 280 . 14 . 14154–67 . April 2005 . 15695810 . 10.1074/jbc.M414265200 . free.
2. Gatzeva-Topalova PZ, May AP, Sousa MC . Crystal structure of Escherichia coli ArnA (PmrI) decarboxylase domain. A key enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance . Biochemistry . 43 . 42 . 13370–9 . October 2004 . 15491143 . 2680612 . 10.1021/bi048551f .
3. Williams GJ, Breazeale SD, Raetz CR, Naismith JH . Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis . The Journal of Biological Chemistry . 280 . 24 . 23000–8 . June 2005 . 15809294 . 3326539 . 10.1074/jbc.M501534200 . free .
4. Gatzeva-Topalova PZ, May AP, Sousa MC . Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance . Structure . 13 . 6 . 929–42 . June 2005 . 15939024 . 2997725 . 10.1016/j.str.2005.03.018 .
5. Yan A, Guan Z, Raetz CR . An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli . The Journal of Biological Chemistry . 282 . 49 . 36077–89 . December 2007 . 17928292 . 2613183 . 10.1074/jbc.M706172200 . free .