Uridine diphosphate glucuronic acid explained

UDP-glucuronic acid is a sugar used in the creation of polysaccharides and is an intermediate in the biosynthesis of ascorbic acid (except in primates and guinea pigs). It also participates in the heme degradation process of human.

It is made from UDP-glucose by UDP-glucose 6-dehydrogenase (EC 1.1.1.22) using NAD+ as a cofactor. It is the source of the glucuronosyl group in glucuronosyltransferase reactions.[1] [2]

See also

Notes and References

  1. Bontemps Y, Vuillermoz B, Antonicelli F, Perreau C, Danan JL, Maquart FX, Wegrowski Y . Specific protein-1 is a universal regulator of UDP-glucose dehydrogenase expression: its positive involvement in transforming growth factor-beta signaling and inhibition in hypoxia . The Journal of Biological Chemistry . 278 . 24 . 21566–75 . Jun 2003 . 12682078 . 10.1074/jbc.M209366200 . free .
  2. Sommer BJ, Barycki JJ, Simpson MA . Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidations . The Journal of Biological Chemistry . 279 . 22 . 23590–6 . May 2004 . 15044486 . 10.1074/jbc.M401928200 . free .

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